Immune Gene Expression

Study of 1,925 Australians links gene variants to immune cell expression at single-cell level

Researchers combined blood samples from two Australian cohorts—the Tasmanian Ophthalmic Biobank and BioHEART—totaling 2,339 recruited individuals, narrowed after quality control to 1,925 people of European ancestry. They used single-cell sequencing to examine how both rare and common genetic variants influence gene expression patterns in individual immune cells.