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Researchers report that water droplets carrying electric charge erode surfaces more aggressively than neutral droplets upon impact. The finding, published via Nature.com, points to charge as an overlooked factor in droplet-driven erosion processes.
Scientists have developed a drug delivery approach that targets specific structures within individual cells rather than simply reaching a cell as a whole. This subcellular precision aims to route therapeutic payloads to particular organelles or compartments where they can act most effectively.
Scientists are developing intranasal vaccines designed to trigger immunity directly in the nose and upper airway, the entry point for many respiratory pathogens. Unlike injected vaccines that mainly prevent severe illness, these formulations aim to stop infection and transmission before a virus can spread further.
Researchers are redesigning drug molecules and delivery systems so a single injection or implant can maintain therapeutic effects for weeks, months, or even years instead of requiring daily dosing. Techniques include chemical modifications that slow drug breakdown, polymer depots, and implantable devices that release medication gradually over extended periods.
A Nature piece argues that even well-designed drugs fail patients if they cannot reach the intended biological target effectively. The commentary highlights delivery mechanisms and targeting accuracy as critical, often underappreciated, factors in therapeutic success.
A Nature editorial argues that a substantial share of prescribed medicines fail to help patients simply because they are not taken as directed. It calls for more research and health-system attention on why patients skip or stop treatments, rather than focusing solely on drug development.
A Nature feature surveys six novel approaches under development for delivering drugs more precisely and effectively, ranging from advanced nanoparticle carriers to devices designed to target specific tissues. These innovations aim to overcome longstanding challenges such as poor bioavailability, degradation before reaching target sites, and off-target side effects.
Scientists are developing genetically modified bacteria designed to seek out and treat tumors from within the body. The approach relies on engineering microbes to recognize cancerous tissue and deliver therapeutic effects directly at the tumor site.
A Nature retrospective highlights the scientific career of William Thomson, later Lord Kelvin, noting that his contributions extended well beyond the temperature scale that bears his name. The piece surveys his broader body of work in physics and engineering during the 19th century.
An editorial in Nature argues that prediction markets allowing wagers on the outcomes of clinical trials pose risks to research integrity and public trust in science. It calls for limits on such betting activity to prevent interference with ongoing trials.
A commentary published in Nature argues that governance frameworks for AI in healthcare should place patients, not just clinicians or regulators, at the center of decision-making. The piece calls for structures that give patients meaningful input into how AI tools are developed, deployed and monitored in clinical settings.
Researchers examined a regulatory protein that controls the cell cycle and found it has an additional, previously unrecognized function tied to breast cancer development. The finding, published via Nature, points to a more complex biological role for this gatekeeper than earlier assumed.