GoKawiilStudy identifies TBK1 and ULK1 as joint regulators of TFEB nuclear translocation under lysosomal stress
Researchers used TBK1-knockout cells and ULK1 knockdown to examine how cells respond to lysosomal stress induced by monensin, nigericin, salinomycin and MG132. Imaging and biochemical analyses showed that loss of TBK1 or ULK1 altered the nuclear-to-cytoplasmic distribution of the transcription factor TFEB, indicating both proteins are needed for its normal activation.