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Open-source project simulates 12 fruit fly brains from real connectome data in one physics scene

A Show HN project called Fly.exe runs a Drosophila brain simulator built from the released male central nervous system connectome — 165,122 neurons and over 25 million synaptic connections — driving a physical fly body model in real time on a single GPU. The demo scales this to twelve independent fly bodies sharing one MuJoCo physics scene, each executing its own copy of the full neural network and interacting through a simplified, analytic form of vision rather than rendered images.

Google's fruit fly brain map gets repurposed to play Doom, Mario 64

Google Research and HHMI Janelia released MaleCNS v1.0, a dataset mapping over 166,000 neurons from a male fruit fly's brain and nervous system, built by converting millions of 2D images into 3D neural reconstructions. Developers quickly began using the model outside its intended scientific purpose, wiring its simulated neurons to control games like Doom and Super Mario 64, where sensory input from game frames drives neural activity that translates into player actions.