Researchers using mouse models traced osteoclast-lineage cells (tdTomato+, CtskCre) in bone marrow and dura mater tissue, comparing their marker expression to invading tumour cells. Using confocal imaging and single-cell RNA sequencing, they characterized osteoclasts and infiltrating tumour cells (ITCs) for markers including DLX5, SCX, TNMD, RUNX2 and COL1A1, showing these cells intersect with meningeal lymphatic structures during dural metastasis.
nature.com
· 2026-09-30
Researchers led by Zeng et al., publishing in Nature, report that tumours spreading to the dura—the brain's outer membrane—recruit bone-degrading osteoclast cells. These osteoclasts damage nearby meningeal lymphatic vessels, which normally drain fluid from around the brain, and weaken local immune defences against the tumour.
nature.com
· 2026-09-30
Researchers analyzing human liver tissue from pancreatic cancer patients, alongside mouse models, report that hepatocytes supply the amino acid serine to metastasizing pancreatic cancer cells, supporting their growth in the liver. The work, which included tissue from the University of Nebraska Medical Center's Rapid Autopsy Program, used immunohistochemistry to examine markers including PHGDH, albumin, CK19, Ki67 and FOXO3A in liver samples.
nature.com
· 2026-09-23
Researchers at the University of Washington collected tissue from 20 bladder cancer patients through a rapid autopsy program, gathering normal tissue, primary tumor samples and up to seven metastases per patient—108 specimens total obtained within hours of death. Samples with high tumor purity were sequenced to trace how bladder cancer spreads and diversifies genetically across different organs in the same patient.
nature.com
· 2026-09-16
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