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Microproteins

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Alzheimer's brains yield over 1,000 unrecognized 'microproteins'

Researchers analyzed human brain tissue samples from people with and without Alzheimer's disease and identified more than 1,000 microproteins that had previously gone undetected. Dozens of these small proteins showed different expression levels in Alzheimer's-affected brains compared with healthy ones. Separately, a mouse study found that immune cells activated by gut infections can travel to the brain's protective membrane and remain there as a lasting defensive memory.

Salk researchers catalogue 4,300+ brain microproteins linked to Alzheimer's disease

Scientists at the Salk Institute and collaborators combined multiple detection techniques to identify over 4,300 previously unrecognized 'microproteins' in postmortem brain tissue from the dorsolateral prefrontal cortex, comparing samples from people with and without Alzheimer's disease. Dozens of these tiny proteins, each under 150 amino acids, showed altered levels in Alzheimer's patients, and the findings were published in Nature Aging on September 14.