GoKawiilMouse and human heart transplant studies find donor age effect fades fast
Researchers led by Jesse Poganik at Brigham and Women's Hospital transplanted young hearts into middle-aged mice and middle-aged hearts into young mice, implanting the extra organ in the neck to compare it with the original. Using three molecular 'aging clocks' to measure biological age, the team found that transplanted hearts largely took on the biological age profile of the recipient rather than retaining the age of the donor, a pattern also suggested by records from human heart transplant recipients.