Mtorc1 - GoKawiil

Study links fly gene Lsp2 to mTORC1-driven ribosomal protein translation and lifespan

Researchers studying Drosophila found that mutating the Lsp2 gene altered translation of TOP mRNAs, particularly those encoding ribosomal proteins, and changed ribosomal subunit ratios and lifespan compared to control flies. They further showed that removing the translational repressor 4E-BP (Thor) shifted how dietary protein levels affect lifespan, without changing mTORC1 activity or overall protein synthesis rates, indicating a specific rather than general translational effect.

nature.com · 2026-09-23

Study finds mTORC1 overactivity alone triggers reactive astrocytes in tuberous sclerosis models

Researchers used gene-edited human pluripotent stem cell lines carrying TSC mutations to generate astrocytes and brain organoids, finding that hyperactivation of the mTORC1 signaling pathway directly causes astrocytes to become reactive without requiring signals from neurons or other cell types. The work relied on multiple hES and hiPS cell lines that were verified for correct gene editing, pluripotency, and genomic integrity before differentiation experiments.

nature.com · 2026-09-23