GoKawiil
Tech News
University of Adelaide scientists led by Chunxia Zhao designed 'smart' nanoparticles that ferry mRNA specifically to tumor-associated macrophages, prompting them to produce CXCL9, a molecule that summons T cells to attack cancer. The approach, described this week in Science Advances, aims to reverse how tumors normally hijack macrophages to block immune attacks.
Scientists are engineering particle-based delivery systems intended to ferry large molecules such as proteins and messenger RNA past the blood-brain barrier, a membrane that normally blocks such compounds from reaching brain tissue. Small chemicals like paracetamol already pass through naturally, but bigger therapeutic molecules cannot, limiting treatment options for brain disorders.
MIT scientists created a new vaccine adjuvant made of mRNA encoding two genes that push immune cells into a more active state via specific signaling pathways. Delivered in lipid nanoparticles in mouse models of bladder, colon, lung and skin cancers, the adjuvant slowed or eliminated tumors even without a cancer-specific vaccine, and worked even better alongside one or with checkpoint inhibitor drugs.