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Neurodegenerative Disease

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Study shows injected human tau fibrils template mouse tau into same structure

Researchers led by Lövestam and colleagues injected fibrils of human tau protein into mice and found that the mice's own tau proteins adopted the same misfolded structure as the injected material. The finding, published in Nature, provides direct structural evidence that tau can act as a template converting normal protein into a toxic form, similar to how infectious prion proteins behave.