GoKawiilLarge psilocybin brain-imaging study finds sharper, not chaotic, neural responses
A large neuroimaging study published in Nature gave 62 psychedelic-naive participants 19mg of oral psilocybin while they meditated, listened to music, or watched a movie, tracking activity across 332 brain regions with fMRI and EEG. Using AI to detect activity patterns tied to each task, researchers found that stronger psilocybin experiences produced clearer, more distinct neural signatures of what people were doing in the moment, even as boundaries between certain brain networks blurred.