Nuclear Pore - GoKawiil

Study maps how sugar tags and importins keep nuclear pore barrier fluid

Researchers engineered a U-2 OS cell line with a fluorescently tagged nucleoporin (NUP96-mEGFP) and a doxycycline-inducible importin-β construct to study the nuclear pore complex's FG-repeat barrier in live cells. Using MINFLUX super-resolution imaging after inducing importin-β expression, they examined how glycosylation and importin binding affect the physical state of this barrier, which controls molecular traffic into and out of the nucleus.

nature.com · 2026-11-11

Study finds nuclear pore barrier proteins behave like liquids

Researchers studying the nuclear pore complex, the structure that controls molecular traffic in and out of a cell's nucleus, found that the disordered proteins forming its selective barrier move and behave like a liquid. This fluid-like motion appears to underlie how the pore filters which molecules can pass through it. The finding was published in Nature.

nature.com · 2026-11-11