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Study finds liver cells feed serine to pancreatic cancer cells to fuel metastasis

Researchers analyzing human liver tissue from pancreatic cancer patients, alongside mouse models, report that hepatocytes supply the amino acid serine to metastasizing pancreatic cancer cells, supporting their growth in the liver. The work, which included tissue from the University of Nebraska Medical Center's Rapid Autopsy Program, used immunohistochemistry to examine markers including PHGDH, albumin, CK19, Ki67 and FOXO3A in liver samples.

nature.com · 2026-09-23

Study links serpin proteins to pancreatic cancer subtype diversity and immune escape

Researchers combined single-cell RNA sequencing from human and mouse pancreatic tumours with protein localization databases, CRISPR dependency screens and functional annotation to identify tumour-secreted genes that shape cancer cell diversity and suppress immune responses. The filtering pipeline pinpointed a group of serpin family proteins acting through myeloid cells as key drivers of this immune evasion process. The work narrows a large pool of candidate genes down to those most likely to influence how pancreatic tumours interact with surrounding immune cells.

nature.com · 2026-09-09