GoKawiilCryo-EM reveals methanogen nitrogenase bound to regulatory PII protein
Researchers used cryo-electron microscopy to resolve the structure of a supercomplex formed between nitrogenase and a PII signal transduction protein in a methanogen archaeon. The structure captures how PII, a widely conserved regulator of nitrogen metabolism, physically associates with the nitrogen-fixing enzyme, offering a molecular view of this interaction not previously visualized at this resolution.