Prime Editing - GoKawiil

Prime Medicine edits human DNA inside the body for first time in Wilson disease trial

Prime Medicine has treated the first patient in a clinical trial using prime editing, a precise gene-editing technique, to correct a mutation in liver cells directly inside the body. The target is Wilson disease, caused by mutations in the ATP7B gene that leave excess copper to build up and damage the liver and nervous system. The company says it expects to report initial trial results next year.

nature.com · 2026-10-22

New 'Prime Assembly' method enables large-scale gene insertion using prime editing

Researchers used K562, Jurkat and HEK293T cell lines to test a genome-editing technique called prime assembly, which combines prime editing components (PE7 or PEmax) with pegRNAs and various DNA donor templates to insert genetic sequences at targeted genomic sites. The team tested donor formats ranging from short synthetic single-stranded DNA to large double-stranded DNA fragments up to 12.1 kilobases, optimizing nucleofection conditions for each donor type.

nature.com · 2026-09-16