Prostate Cancer - GoKawiil

Study ties tRNA gene dosage to prostate cancer lineage shifts and drug resistance

Researchers at the Fred Hutchinson Cancer Center analyzed metastatic prostate cancer samples and cell line models, including treatment-resistant variants, to study how transfer RNA (tRNA) abundance influences tumor behavior. The work examined patient tumor samples collected via rapid autopsy alongside multiple prostate cancer cell lines adapted to mimic lineage plasticity and resistance to androgen-deprivation therapy.

nature.com · 2026-10-07

Study maps mutational signatures behind prostate cancer using largest PPCG genome dataset

Researchers analyzed whole-genome sequencing data from 1,001 prostate cancer patients (1,172 tumour samples) collected through the PPCG consortium, applying computational tools to classify structural variants, including simple, complex, and chromothripsis-related genomic rearrangements. The team combined breakpoint detection, copy number segmentation, and statistical tests to build a detailed picture of mutational processes driving the disease.

nature.com · 2026-09-09