Reprogramming - GoKawiil

MIT Technology Review to host live discussion on AI extinction risk; researcher's eye age-reversal therapy enters human trials

MIT Technology Review is holding a subscriber-only roundtable on September 15 with editors and an AI reporter to examine claims that artificial intelligence poses an extinction-level threat to humanity. Separately, the outlet profiles geneticist Yuancheng (Ryan) Lu, whose cellular reprogramming technique reversed blindness in mice by repairing optic nerves, and reports that a similar gene therapy has now moved into human clinical trials. Lu was also named to the publication's 2026 list of top young innovators in biotechnology and health.

technologyreview.com · 2026-09-14

Life Biosciences begins human trial of Yuancheng Lu's age-reversal gene therapy for glaucoma

Geneticist Yuancheng Lu, working in David Sinclair's Harvard lab, developed a reprogramming gene therapy in 2018 that regenerated crushed optic nerves in mice and restored their vision. That same therapy, now called ER-100, has been adapted for humans by the startup Life Biosciences, which in June injected it into the eye of a glaucoma patient as part of a clinical trial.

technologyreview.com · 2026-09-08