GoKawiilProposal calls for enzyme that reverse-translates proteins into DNA or RNA
A proposed grand challenge in biology asks researchers to engineer a protein catalyst capable of reading an unlabeled peptide chain and writing a corresponding nucleic acid strand without relying on a template, barcode, or lookup database. Success would require demonstrating the method on at least 100 preregistered random peptides of 50+ amino acids, achieving 90% sequence accuracy, average read lengths above 25 residues, and quality scores of at least Q10.