GoKawiil
Tech News
Stanford University researchers led by Sergiu Pașca transplanted lab-grown human brain organoids into mice bred to lack most of their cerebral cortex. The transplanted tissue survived and formed functional connections to the animals' brains and spinal cords, according to a study published in Nature. The team describes it as the most extensive integration of human brain cells into an animal achieved to date.
Stanford scientists genetically engineered mice lacking a functioning cortex, then implanted human neurons derived from reprogrammed skin cells into the empty space. The transplanted cells multiplied from a few hundred to several million and wired themselves into the mouse brain, with the animals behaving largely normally despite the human tissue making up nearly half their brain volume by some measures. The findings were published in Nature.
A Stanford team led by Sergiu Pașca genetically engineered mice to lack most of their cortex and hippocampus, then implanted human brain organoid cells into the resulting gap. The human cells expanded to fill much of that space within weeks to months, and mice with the human tissue performed better on memory maze tests than mice without it.
Researchers led by Sergiu Pașca at Stanford transplanted lab-grown human brain tissue into newborn mice missing part of their brains, and the tissue expanded to fill much of that space while forming functional connections with the host nervous system. Published in Nature on September 16, the study represents the most extensive fusion of human neural tissue into a living animal achieved to date, though behavioral tests showed the mice did not gain enhanced cognitive abilities.