GoKawiilStudy maps human fetal heart cell development disrupted by Trisomy 21
Researchers analyzed single-nucleus and spatial transcriptomic data from human embryonic and fetal heart tissue samples, obtained from terminated pregnancies under ethical approval from UK research bodies including Cambridge University Hospitals and the Human Developmental Biology Resource at UCL. The study aimed to characterize how heart cells normally develop and how this process is altered in fetuses with Trisomy 21 (Down syndrome).