GoKawiilStudy identifies TCR-dependent mechanism shaping γδ T cell tissue surveillance
Researchers used mouse models with tamoxifen-inducible deletion of the Trgc1 gene, which encodes a component of the γδ T cell receptor, to study how these cells patrol tissues like skin and intestine. By selectively removing the receptor gene in specific cell populations and tracking receptor signaling with reporter mice, they examined how TCR expression influences γδ T cell behavior and distribution across tissues.