GoKawiilStudy links fly gene Lsp2 to mTORC1-driven ribosomal protein translation and lifespan
Researchers studying Drosophila found that mutating the Lsp2 gene altered translation of TOP mRNAs, particularly those encoding ribosomal proteins, and changed ribosomal subunit ratios and lifespan compared to control flies. They further showed that removing the translational repressor 4E-BP (Thor) shifted how dietary protein levels affect lifespan, without changing mTORC1 activity or overall protein synthesis rates, indicating a specific rather than general translational effect.