Tuberous Sclerosis

Journal Issues Author Correction for Tuberous Sclerosis Astrocyte Study

The authors of a paper on mTORC1 and astrocyte reactivity in tuberous sclerosis have issued a correction addressing several figure errors. These include a duplicated panel in Figure 3n, transposed cluster labels in an Extended Data Figure 3 caption, and a mislabeled sample in Extended Data Figure 10c. The publisher has updated both the HTML and PDF versions of the article to reflect these fixes.

nature.com · 2026-11-02

Study finds mTORC1 overactivity alone triggers reactive astrocytes in tuberous sclerosis models

Researchers used gene-edited human pluripotent stem cell lines carrying TSC mutations to generate astrocytes and brain organoids, finding that hyperactivation of the mTORC1 signaling pathway directly causes astrocytes to become reactive without requiring signals from neurons or other cell types. The work relied on multiple hES and hiPS cell lines that were verified for correct gene editing, pluripotency, and genomic integrity before differentiation experiments.

nature.com · 2026-09-23