Wdr4

Researchers detail small-molecule METTL1 inhibitor effective against solid and blood cancers

A new study presents a pharmacological inhibitor targeting METTL1, an enzyme that modifies RNA, and reports that blocking its activity suppresses growth in both solid tumour and blood cancer models. The paper also describes the biochemical methods used, including expression and purification of the full-length METTL1–WDR4 protein complex, to support structural and functional characterization of the drug target.