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Gene-edited pancreatic cells transplanted into a patient with type 1 diabetes

news.ycombinator.com Javier Carbajal 2025-10-04 06:45:28

Crispr gene-editing technology has demonstrated its revolutionary potential in recent years: It has been used to treat rare diseases, to adapt crops to withstand the extremes of climate change, or even to change the color of a spider’s web. But the greatest hope is that this technology will help find a cure for a global disease, such as diabetes. A new study points in that direction. For the first time, researchers succeeded in implanting Crispr-edited pancreatic cells in a man with type 1 diab

Topics: cells diabetes immune insulin patient

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Becoming the person who does the thing

news.ycombinator.com Fred Rivett 2025-10-05 03:24:36

It can be disorienting when our beliefs shift. The world we helped create no longer exists, and our role in it transforms too. It can be unsettling, naturally. But that's kind of the point. Looking back at times when I held certain beliefs—about how the world works, and what my role in this story is—it can feel less like a mod was installed and more like an entirely new operating system was swapped in. Up until my late twenties, I could count the number of times I had been to the gym on one h

Topics: beliefs day identity like new

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8 Best Espresso Machines for Home (2025), Tested by Coffee Pros

wired.com Matthew Korfhage 2025-10-05 03:32:00

Compare the Top 8 Espresso Machines Other Machines We Like Photograph: Matthew Korfhage Meraki Espreso Machine for $2,000: Meraki is a young Hong Kong–based company. Last year it was still Kickstarting funds for its debut Meraki Espresso Machine. But the company started off with a bang, with a premium semiautomatic double-boiler machine offering features you don't find even in machines that cost hundreds more. This means a Timemore grinder that'll grind by weight within two-tenths of a gram p

Topics: breville espresso grinder like machine

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VPNs and Age-Verification Laws: What You Need to Know

wired.com Jacob Roach 2025-10-05 04:30:00

The problem is how the verification happens. You aren’t verifying your age with the government. You’re routing it through an independent third party, and most of the laws on the books are designed specifically in this way. In the UK, for example, Reddit verifies with Persona, and Bluesky uses Kids Web Services (owned by Epic Games). Persona’s privacy policy states that it collects not only biometric information and personal details, like your ID, but also ties that to information gathered from

Topics: internet server traffic vpn vpns

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Sony’s new Xperia phone jumps on the camera bar bandwagon

theverge.com Dominic Preston 2025-10-05 04:02:52

is a news editor with over a decade’s experience in journalism. He previously worked at Android Police and Tech Advisor. Posts from this author will be added to your daily email digest and your homepage feed. Sony has announced the Xperia 10 VII, a midrange Android phone that’s launching in the UK, Europe, and Asia, though not the US. It’s more notable than most Sony phones because it marks the first major change to the rear design in over five years: a camera bar, just like recent Pixels, and

Topics: 10 design phone sony xperia

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Will the latest iPhone kill off the SIM card?

feeds.bbci.co.uk Unknown 2025-10-05 02:27:58

Will the latest iPhone kill off the SIM card? 4 hours ago Share Save Graham Fraser Technology reporter Share Save Getty Images With smartphones, where Apple leads others often follow - so it launching an iPhone this week without a traditional SIM card is raising questions over the future of a very familiar piece of phone tech. All phone users will be used to the small plastic cards they need to delicately insert into their devices to make them operate. But for buyers of the iPhone Air, that w

Topics: card esim iphone physical sim

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Apple Store is down ahead of iPhone 17, iPhone 17 Pro and iPhone Air preorders

9to5mac.com Benjamin Mayo 2025-10-05 04:37:00

It’s new iPhone preorder day, which means Apple is following the usual tradition of taking down the store a few hours ahead. The store will be back up at 5 AM Pacific Time. Today, customers can order iPhone 17, iPhone 17 Pro and iPhone Air for (hopefully) launch day delivery on September 19. AirPods Pro 3 and the new Apple Watch models are already available to order. The new iPhone lineup spans from $799 to $1199 starting prices. All new iPhones have 256 GB storage as the base configuration.

Topics: 17 apple iphone new pro

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YouTube Music rolls out dual-pane Now Playing redesign on Android, iOS

9to5mac.com Abner Li 2025-10-05 04:45:16

After testing first got underway in November, YouTube Music is now rolling out a big Now Playing redesign on Android and iOS. The Song/Video switcher is no longer at the top of Now Playing, but Cast remains next to the three-dot overflow menu. After the song name (which can be tapped to access Related) and artist, you now get the controls row. This does not really impact one-handed usage, but it does move things further up the screen. This is followed by a new boxy scrubber that gets rid of t

Topics: music new playing song youtube

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Performance-focused forks of styled-components

news.ycombinator.com Unknown 2025-10-05 05:00:52

Your React app might be 40% slower on first render than it needs to be. Not because you wrote bad code. Not because React is slow. But because styled-components never implemented React 18's useInsertionEffect hook: a feature specifically designed to solve CSS-in-JS performance problems. While React 18 shipped in March 2022 with this optimization path, styled-components remained on React 17 patterns, injecting styles during render instead of between render and layout. This creates a performanc

Topics: components performance react styled styles

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FDA Clears the Apple Watch for Hypertension Alerts

cnet.com See Full Bio 2025-10-05 01:14:00

On Thursday the Food and Drug Administration cleared a new hypertension detection tool for the Apple Watch. The health feature was one of the highlights at Apple's September iPhone event and will alert Apple Watch owners of potential signs of high blood pressure, a condition that goes undiagnosed in millions of people. In addition to the FDA clearing Apple's chronic high blood pressure tool, the Cupertino company announced that it will be available on its watches starting next week in 150 count

Topics: apple new score sleep watch

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Apple Watch hypertension alerts cleared by FDA for new and old watches

theverge.com Thomas Ricker 2025-10-05 04:10:41

is a deputy editor and Verge co-founder with a passion for human-centric cities, e-bikes, and life as a digital nomad. He’s been a tech journalist for 20 years. Posts from this author will be added to your daily email digest and your homepage feed. Starting next week, Apple’s new hypertension notification feature will be coming to Watch Series 9 and later and Apple Watch Ultra 2 and later with the launch of watchOS 26. That’s according to an emailed statement from Apple spokesperson Zaina Khac

Topics: apple blood heart new watch

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Asus gives its $4,000 creator laptop a 4K tandem OLED and RTX 5090

theverge.com Antonio G. Di Benedetto 2025-10-05 05:30:00

is a reviewer covering laptops and the occasional gadget. He spent over 15 years in the photography industry before joining The Verge as a deals writer in 2021. Asus’ ProArt P16 laptop is getting RTX 50-series GPUs and a unique new screen in its high-end configuration. Its biggest upgrades include Nvidia’s top-tier RTX 5090 mobile GPU and a bright 16-inch 3840 x 2400 tandem OLED touchscreen, capable of up to 1,600 nits of brightness in HDR and 120Hz refresh with VRR. The new flagship P16 will c

Topics: asus new p16 rtx zephyrus

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The Samsung Galaxy Z Flip 7 is still at its record-low price

androidauthority.com Unknown 2025-10-05 02:38:45

Joe Maring / Android Authority Galaxy Z Flip 7 There have been more exciting deals on the Samsung Galaxy Z Fold 7 and Galaxy Z Flip 7 FE lately, so the Samsung Galaxy Z Flip 7 hasn’t gotten the attention it deserves. All the other discounts are gone, though, and now it’s time to give the Samsung Galaxy Z Flip 7 the spotlight. It is $150 off! Buy the Samsung Galaxy Z Flip 7 for just $949.99 ($150 off) This offer is available from Amazon. The discount is available in all available color versions

Topics: display flip galaxy phone samsung

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The effects of algorithms on the public discourse

news.ycombinator.com Unknown 2025-10-05 03:39:47

We traded blogs for black boxes, now we're paying for it 09/09/2025 Come listen to the "old man yelling at clouds" in me for a bit. tl;dr: The internet is changing for the worse (or getting 'enshittified'). In this post, I write about the effects of algorithms on the public discourse to illustrate a greater point on the enshittification of the internet. Then, I offer my personal notes and curated resources to guide you on your personal internet deshittification journey. I miss the old intern

Topics: algorithm internet people use way

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This Pop-Out Phone Controller Could Reinvent How We Think of Mobile Gaming

gizmodo.com Kyle Barr 2025-10-05 05:00:17

Today’s retro recreations are so good at replicating the Game Boy’s look, feel, and portability. The problem is, my pockets are already occupied with my mobile supercomputer that contains my life behind a 6.3-inch pane of glass. If my phone has a powerful processor and excellent AMOLED display, why can’t it also become my gaming device when I’m on the go? MCON, the controller hyped to hell and back by young engineer Josh King and brought to market by phone peripheral makers OhSnap, could be enou

Topics: controller feel game mcon phone

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The FDA Clears the Apple Watch for Hypertension Alerts

cnet.com See Full Bio 2025-10-05 06:14:43

On Thursday the Food and Drug Administration cleared a new hypertension detection tool for the Apple Watch. The health feature was one of the highlights at Apple's September iPhone event and will alert Apple Watch owners of potential signs of high blood pressure, a condition that goes undiagnosed in millions of people. In addition to the FDA clearing Apple's chronic high blood pressure tool, the Cupertino company announced that it will be available on its watches starting next week in 150 count

Topics: apple new score sleep watch

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iMazing 3 gives you full control of your iPhone, with a 20% discount

9to5mac.com Sponsored Post 2025-10-05 07:38:27

iMazing started life as a more powerful and flexible alternative to iTunes, but has since grown into a comprehensive desktop solution for managing Apple mobile devices across personal, educational, and professional contexts. Just in time for the iPhone 17, iMazing is offering readers a limited 20% discount on all licenses with the code: 9to5mac-20off. While the app was originally designed for consumers, the addition of new features in recent versions has attracted business and enterprise users

Topics: apple devices imazing iphone users

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These budget open-ear headphones just got cheaper, plus get a free Anker charger - here's how

zdnet.com Monica Bell 2025-10-05 07:41:10

Now is the perfect time to plunge if you've considered trying out open-ear headphones. Soundcore V40i's open-ear headphones are now on sale for a 25% off, and they were already affordable. Right now, you can grab them for only $60. This deal includes a lidless case, four adjustable earbud positions to fit every ear, and a free Anker Nano USB-C charger block. Also: These subtle AirPods Pro 3 upgrades would make them an instant buy for me Wearing open-ear headphones over traditional earbuds is d

Topics: charger deal ear headphones zdnet

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‘Wednesday’ Star Evie Templeton on Agnes’ Progression From Stalker to Friend

gizmodo.com Sabina Graves 2025-10-05 07:40:47

During a chat on the official Wednesday podcast—or rather, woecast—Nevermore newcomer Evie Templeton discussed Agnes coming into her own after being an unhinged stalker fan of Netflix’s favorite Addams. After Wednesday (Jenna Ortega) lays into her at the end of the second season of the Tim Burton show, seemingly to push her to be herself in the meanest way possible, Agnes gets gutted emotionally in a way that could have been a villain origin but goes in a surprisingly positive direction. “I th

Topics: agnes moment really think wednesday

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GrapheneOS and forensic extraction of data (2024)

news.ycombinator.com Unknown 2025-10-05 01:46:27

Matthai Hi, I am writing an article and I am sharing a draft with you. I will be glad if you share your thoughts and suggestions with me. GrapheneOS is an Android-based, open source, privacy and security-focused mobile operating system for mobile phones. It is one of the most secure and privacy protecting operating systems (and yes, it does this task comparable and in some scenarios even better than iOS, but we will come to that later). However, in the beginning of May, someone started an at

Topics: data device grapheneos phone unlock

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Doorbell prankster that tormented residents of apartments turns out to be a slug

news.ycombinator.com Kate Connolly 2025-10-02 03:33:26

Inhabitants of an apartment block in Bavaria, southern Germany, who called police to investigate the relentless buzzing of their doorbells late at night were surprised to find the culprit was not a teenage prankster as they had suspected, but a slug. The slug had been sliding up and down the bell plate, creating havoc in the building and tearing angry residents out of their beds long after midnight when they could not sleep for the noise. At first they had suspected the so-called klingelstreic

Topics: account bell door newsletter police

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Building my childhood dream PC

news.ycombinator.com Unknown 2025-10-01 19:05:54

May 1, 2025 Building my childhood dream PC In 1993, I was 14 and already passionate about computers[1]. That year my mother managed to buy a PC for the household. That was quite an effort for a single mother. My brother Aurelien and I spent every waking hour on this machine, staying up all night on weekends. Discovering the architecture of the PC, learning to program it, exploring how to manage its memory with CONFIG.SYS and AUTOEXEC.BAT , installing isa cards, drawing with Deluxe Paint, and

Topics: 2168 ibm machine pc ps

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Someone Finally Got the Note and Fixed This ‘Beetlejuice’ Sign

gizmodo.com Sabina Graves 2025-10-05 11:00:33

If you’re a movie prop replica collector, you know exactly which Beetlejuice sign we’re talking about. For years, as a Beetlejuice decor hunter, there has been one item I refused to buy on principle because it had one glaring mistake: it was not in-universe accurate. I’ve bought the Adam and Barbara monster face hanging decor, the inflatable Sandworm for my lawn, and the “Here Lies Betelgeuse” tombstone—but never the iconic light-up sign due to the fact that it always featured the ghost with th

Topics: beetlejuice betelgeuse decor sign tombstone

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Order a Case for Your New iPhone 17 Ahead of Tomorrow's Preorder Launch

cnet.com Aashna Gheewalla 2025-10-05 06:53:00

The world is buzzing with excitement about Apple's new flagship. The iPhone 17 lineup was announced at the company's Apple Event 2025 earlier this week. It includes the base iPhone 17, the new iPhone Air and the 17 Pro, as well as the larger 17 Pro Max. You can start preordering the new phone tomorrow, Sept. 12, but don't forget to grab something to protect it. Some of your favorite brands, like Casetify, have already released new cases for the upcoming iPhone 17 models. Even Apple has dropped i

Topics: 17 cases close iphone starting

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Google Home’s feature-packed new automation editor is ready for you to try out now

androidauthority.com Unknown 2025-10-05 15:59:58

Edgar Cervantes / Android Authority TL;DR Google Home is rolling out a new automation editor experience on Android and iOS. The editor supports conditions, adds new actions and triggers, and just empowers more complicated automations. While some features aren’t yet working, you still have the option to go back to the old editor. Having a proper smart home means more than just installing some Wi-Fi lightbulbs, smart outlets, and security cameras. If you really want to get the most out of all

Topics: editor google just like new

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iPhone 17, iPhone Air, AirPods Pro 3, and Apple Watch Series 11 event reactions

9to5mac.com Chance Miller 2025-10-05 15:27:48

Benjamin and Chance react to the September Apple event, with opinions in keynote order. Chance was there in person, so that includes some early hands-on thoughts of these new devices. That includes Apple’s unveiling of the new AirPods Pro 3, Apple Watch Series 11, iPhone 17, iPhone Air and the unmistakably orange iPhone 17 Pro series. And in Happy Hour Plus, the pair talk about what products they are buying from this week’s announcements, and some more on Chance’s experience at Apple Park. Subs

Topics: 9to5mac chance com happy iphone

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"Building my childhood dream PC" (IBM 2168) Part 1

news.ycombinator.com Unknown 2025-10-02 00:05:54

May 1, 2025 Building my childhood dream PC In 1993, I was 14 and already passionate about computers[1]. That year my mother managed to buy a PC for the household. That was quite an effort for a single mother. My brother Aurelien and I spent every waking hour on this machine, staying up all night on weekends. Discovering the architecture of the PC, learning to program it, exploring how to manage its memory with CONFIG.SYS and AUTOEXEC.BAT , installing isa cards, drawing with Deluxe Paint, and

Topics: 2168 ibm machine pc ps

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The Boring Company Reportedly Halts Tunneling in Las Vegas After ‘Crushing Injury’

gizmodo.com Matt Novak 2025-10-05 15:30:54

Elon Musk’s tunneling firm, The Boring Company, has temporarily halted work at one of the company’s sites in Las Vegas, Nevada, according to a new report from Fortune. The disruption is related to a “crushing injury” sustained by one of the workers at the site, according to the magazine, which spoke to local firefighters. Emergency responders received a call around 10:12 p.m. local time on Wednesday night about an “industrial/machinery incident,” according to Fortune. Employees at the worksite

Topics: according company fortune las vegas

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Today's NYT Connections Hints, Answers and Help for Sept. 12, #824

cnet.com See Full Bio 2025-10-05 14:00:02

Looking for the most recent Connections answers? Click here for today's Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle, Connections: Sports Edition and Strands puzzles. Today's NYT Connections puzzle is tricky -- it contains one of those purple categories where you have to mentally subtract a letter from four related words to see how they connect. Read on for clues and today's Connections answers. The Times now has a Connections Bot, lik

Topics: answers connections group today words

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Today's NYT Connections: Sports Edition Hints and Answers for Sept. 12, #354

cnet.com See Full Bio 2025-10-05 14:00:04

Looking for the most recent regular Connections answers? Click here for today's Connections hints, as well as our daily answers and hints for The New York Times Mini Crossword, Wordle and Strands puzzles. Today's Connections: Sports Edition is a fun mix. When I saw "inside-the-park," I figured that could only mean one category, but some of the others were trickier. If you're stuck but still want to solve it, read on for hints and the answers. Connections: Sports Edition is published by The Ath

Topics: answers connections group sports today

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Latest Tech News

Gene-edited pancreatic cells transplanted into a patient with type 1 diabetes

Becoming the person who does the thing

8 Best Espresso Machines for Home (2025), Tested by Coffee Pros

VPNs and Age-Verification Laws: What You Need to Know

Sony’s new Xperia phone jumps on the camera bar bandwagon

Will the latest iPhone kill off the SIM card?

Apple Store is down ahead of iPhone 17, iPhone 17 Pro and iPhone Air preorders

YouTube Music rolls out dual-pane Now Playing redesign on Android, iOS

Performance-focused forks of styled-components

FDA Clears the Apple Watch for Hypertension Alerts

Apple Watch hypertension alerts cleared by FDA for new and old watches

Asus gives its $4,000 creator laptop a 4K tandem OLED and RTX 5090

The Samsung Galaxy Z Flip 7 is still at its record-low price

The effects of algorithms on the public discourse

This Pop-Out Phone Controller Could Reinvent How We Think of Mobile Gaming

The FDA Clears the Apple Watch for Hypertension Alerts

iMazing 3 gives you full control of your iPhone, with a 20% discount

These budget open-ear headphones just got cheaper, plus get a free Anker charger - here's how

‘Wednesday’ Star Evie Templeton on Agnes’ Progression From Stalker to Friend

GrapheneOS and forensic extraction of data (2024)

Doorbell prankster that tormented residents of apartments turns out to be a slug

Building my childhood dream PC

Someone Finally Got the Note and Fixed This ‘Beetlejuice’ Sign

Order a Case for Your New iPhone 17 Ahead of Tomorrow's Preorder Launch

Google Home’s feature-packed new automation editor is ready for you to try out now

iPhone 17, iPhone Air, AirPods Pro 3, and Apple Watch Series 11 event reactions

"Building my childhood dream PC" (IBM 2168) Part 1

The Boring Company Reportedly Halts Tunneling in Las Vegas After ‘Crushing Injury’

Today's NYT Connections Hints, Answers and Help for Sept. 12, #824

Today's NYT Connections: Sports Edition Hints and Answers for Sept. 12, #354

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