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What's going on with gene therapies?

news.ycombinator.com Nehal Udyavar 2025-07-18 04:48:53

Tree of Hope, Remain Strong (1946) by Frida Kahlo First attempts in a new field of medicine rarely go according to plan. On September 14, 1990, Dr. William French Anderson and his team at the National Institute of Health (NIH) performed the first official gene therapy trial. The patient, a 4-year-old Ashanti deSilva, suffered from a rare genetic disease called adenosine deaminase (ADA) deficiency, a form of severe combined immune deficiency (SCID). Children with ADA-SCID rarely make it to adult

Topics: cell cells gene months therapy

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What's going on with gene therapies? (Part one)

news.ycombinator.com Nehal Udyavar 2025-07-18 14:48:53

Tree of Hope, Remain Strong (1946) by Frida Kahlo First attempts in a new field of medicine rarely go according to plan. On September 14, 1990, Dr. William French Anderson and his team at the National Institute of Health (NIH) performed the first official gene therapy trial. The patient, a 4-year-old Ashanti deSilva, suffered from a rare genetic disease called adenosine deaminase (ADA) deficiency, a form of severe combined immune deficiency (SCID). Children with ADA-SCID rarely make it to adult

Topics: cell cells gene months therapy

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A recap on May/June stability at Neon

news.ycombinator.com Nikita Shamgunov 2025-07-22 01:22:57

Details of incidents and what we did to prevent more in the future Starting in May, we had a series of feature launches with agentic AI partners that gained far more momentum than we predicted. In two short timespans, the rate of new database creation increased more than 5x, and the rate of branch creation increased more than 50x. While we were humbled by the uptick, the significant burst in operational load caused a lot of strain in the Neon platform, manifesting as more incidents over the cou

Topics: cells database databases incidents project

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A Recap on May/June Stability at Neon

news.ycombinator.com Nikita Shamgunov 2025-07-22 11:22:57

Details of incidents and what we did to prevent more in the future Starting in May, we had a series of feature launches with agentic AI partners that gained far more momentum than we predicted. In two short timespans, the rate of new database creation increased more than 5x, and the rate of branch creation increased more than 50x. While we were humbled by the uptick, the significant burst in operational load caused a lot of strain in the Neon platform, manifesting as more incidents over the cou

Topics: cells database databases incidents project

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GM’s Final EV Battery Strategy Copies China’s Playbook: Super Cheap Cells

wired.com John Voelcker 2025-07-28 00:21:12

General Motors has just announced its latest and likely final piece in what now appears to be a three-pronged cell-chemistry strategy to power GM’s lineup of a dozen EVs through the end of the decade and beyond. GM has stated today it will build low-cost lithium iron phosphate (LFP) battery cells in Spring Hill, Tennessee, starting in late 2027. Conversion of cell lines to produce that chemistry will begin later this year. The cell plant at the Spring Hill complex is owned and operated by Ultiu

Topics: cell cells chemistry gm lfp

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GM to challenge China’s LFP monopoly with upgraded battery factory

techcrunch.com Tim De Chant 2025-07-28 00:04:11

GM said Monday it is working with joint venture partner LG Energy Solution to upgrade its Ultium battery factory to make lithium-iron-phosphate cells for the automaker’s low-cost EVs. The factory’s overhaul will give LFP production in the United States a significant boost. Despite being invented and commercialized in the U.S., today the vast majority of LFP cells are currently made in China. The $2.3 billion Spring Hill, Tennessee, battery plant is part of the Ultium Cells LLC joint venture be

Topics: battery cells chemistry gm lfp

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Stem Cell Treatment to Reverse Hearing Loss Kicking Off in Human Patients

futurism.com Unknown 2025-07-28 13:15:43

Image by Getty / Futurism Developments The first-ever human trial exploring the use of stem cell therapy to reverse hearing loss is about to be under way, after getting the go-ahead from the UK’s Medicines and Healthcare products Regulatory Agency. Conducted by researchers from the University of Sheffield who formed their own spin-out company, the treatment targets sensorineural hearing loss, which is caused by physical damage to the tiny structures of the inner ear. In a nutshell, the treatm

Topics: cells ear hearing inner stem

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Mighty mitochondria: Cell powerhouses harnessed for healing

arstechnica.com Unknown 2025-08-02 09:10:31

James McCully was in the lab extracting tiny structures called mitochondria from cells when researchers on his team rushed in. They’d been operating on a pig heart and couldn’t get it pumping normally again. McCully studies heart damage prevention at Boston Children’s Hospital and Harvard Medical School and was keenly interested in mitochondria. These power-producing organelles are particularly important for organs like the heart that have high energy needs. McCully had been wondering whether t

Topics: cells damage heart mccully mitochondria

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Making Explainable Minesweeper

news.ycombinator.com Unknown 2025-07-30 12:56:04

🎮Game 🧩Puzzle 💣Minesweeper 🤖Algorithm 💻Game Dev Background I recently purchased and played a game called 14 Minesweeper Variants during a Steam Summer sale. It was a fun game. However, I became curious while looking at the hints provided in the game. What exactly are these? Actually, when I played Minesweeper, which was a default Windows game, I could solve cases where there was a definite answer, but I remember stepping on countless mines in ambiguous situations. For example, situations like

Topics: area cells deduction game mines

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Scientists Discover Secret Weapon That Allows Pythons to Digest Bones

gizmodo.com Ellyn Lapointe 2025-08-04 18:00:40

Pythons are notorious for their eating habits. After suffocating their prey with their lithe bodies, these large snakes swallow the animal whole. Now, researchers have shed new light on the cellular mechanisms that allow them to digest entire skeletons. The study, presented July 9 at the Society for Experimental Biology Annual Conference in Belgium and published in the Journal of Experimental Biology, investigated the intestinal cells of Burmese pythons. Adult males can grow to be 10 to 16 feet

Topics: calcium cells particles pythons snakes

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At the frontier between two lives–the evolutionary origins of pregnancy

news.ycombinator.com University Of Vienna 2025-08-02 08:17:47

This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility: Single-cell transcriptomic atlases of six mammalian species spanning the diversification of viviparity. Credit: Nature Ecology & Evolution (2025). DOI: 10.1038/s41559-025-02748-x An international research team led by scientists from the University of Vienna has uncovered new insights into how specialized cell types

Topics: cell cells evolution fetus maternal

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New Research Debunks Myth That Brain Cells Stop Growing After Childhood

gizmodo.com Ed Cara 2025-08-12 08:00:50

You’ve probably heard the old canard that new brain cells simply stop forming as we become adults. But research out today is the latest to show that this isn’t really true. Scientists in Sweden led the study, published Thursday in Science. They found abundant signs of neural stem cells growing in the hippocampus of adult brains. The findings reveal more about the human brain as we get older, the researchers say, and also hint at potential new ways to treat neurological disorders. “We’ve found

Topics: adult brain cells neurogenesis new

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Serenading Cells with Audible Sound Alters Gene Activity

news.ycombinator.com Simon Makin 2025-08-10 22:04:53

The cells in your ears aren’t the only ones listening: recent research suggests that crucial cells throughout the body may respond to audible sound. Experiments described in Communications Biology revealed more than 100 genes whose activity changed in response to these acoustic waves, pointing to possible medical applications. Extensive earlier research has shown that ultrasound—sound at frequencies higher than humans can hear—can affect biology in numerous ways; the new study expands this conc

Topics: activity audible cells genes sound

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Genetic code enables zebrafish to mend damaged organs

news.ycombinator.com Unknown 2025-08-16 04:00:11

Zebrafish have the remarkable and rare ability to regrow and repair their hearts after damage. New research from Caltech and UC Berkeley has identified the circuit of genes controlling this ability and offers clues about how a human heart might someday be repaired after damage, such as a heart attack or in cases of congenital heart defects. The research was a collaboration between the laboratories of Marianne Bronner, Caltech's Edward B. Lewis Professor of Biology and director of the Beckman In

Topics: cells crest genes heart neural

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Biologists Uncover Previously Unknown Structure Hiding Inside Human Cells

gizmodo.com Natalia Mesa 2025-08-20 16:00:57

Even after decades of peering into cells, biologists are still finding surprises. In a twist, researchers at the University of Virginia and the National Institutes of Health uncovered a new organelle, dubbed the hemifusome. This tiny membrane-bound structure serves as a cellular recycling center and may hold the key to treating several genetic diseases. The research has been published in Nature Communications. “This is like discovering a new recycling center inside the cell,” co-author Seham E

Topics: cell cells ebrahim genetic hemifusomes

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Notorious Fungus Blamed for ‘Mummy’s Curse’ Is Now a Promising Cancer Treatment

gizmodo.com Margherita Bassi 2025-08-20 09:00:30

In the 1920s, a number of workers on the excavation team that uncovered King Tutankhamun’s tomb met untimely deaths. Five decades later, 10 out of 12 scientists died after entering the tomb of the 15th-century Polish King Casimir IV. In both cases, researchers suggested that fungal spores could have played a role in the mysterious deaths, specifically identifying the fungus Aspergillus flavus within the Polish burial. A. flavus is now making a comeback, but not as a reawakened killer from ancie

Topics: asperigimycins cancer cells researchers ripps

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New research links caffeine to slower aging at the cellular level

techspot.com Alfonso Maruccia 2025-08-23 12:12:00

High on Caffeine: Caffeine is the most widely consumed psychoactive substance in the world, and it's found almost everywhere. People consume it through coffee, tea, soft drinks, energy drinks, and more. According to new research, caffeine may do more than just help you stay awake after a long night – it could have other surprising benefits as well. A recently published study confirms what caffeine enthusiasts have suspected all along: the naturally occurring stimulant is not only great for waki

Topics: ampk caffeine cells cellular energy

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Now Google’s Gemini AI is ready to fill in those empty cells in your spreadsheet

theverge.com Emma Roth 2025-08-24 00:17:20

is a news writer who covers the streaming wars, consumer tech, crypto, social media, and much more. Previously, she was a writer and editor at MUO. Google is launching a new AI function in Sheets to help you generate text to fill out parts of your spreadsheet. The feature, powered by Google Gemini, can reference specific cells to create text, summarize information, or categorize your data. In the example shared by Google, you can use the new AI function to generate and tailor copy for an adver

Topics: ai cells copy function google

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Diabetic Woman No Longer Needs Insulin After Single Dose of Experimental Stem Cells

futurism.com Unknown 2025-08-29 00:24:45

Image by Getty / Futurism Treatments A Canadian woman with type 1 diabetes spent nearly a decade dependent on her glucose monitor and insulin shots — but after a single dose of manufactured stem cells implanted into her liver, she's now free. In an interview with CTV, 36-year-old Amanda Smith of London, Ontario described how it felt to be part of such a groundbreaking experiment that has allowed her body to once again produce its own insulin. "I remember, like, being scared and excited," Smit

Topics: cells insulin said smith stem

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2048 with only 64 bits of state

news.ycombinator.com Unknown 2025-08-28 16:43:17

This is an implementation of the classic 2048 game in your terminal: Share your game state with friends by just sending them a number! If the $STATE env variable isn't set, it generates a fresh random seed. Otherwise the board state and all future spawned cells will be deterministic.

Topics: 2048 cells deterministic game state

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Virtual cells

news.ycombinator.com Unknown 2025-08-30 08:18:38

Virtual cells Digital twins of biological cells—often referred to as virtual cells or whole-cell models (WCMs)–aim to recreate every relevant molecular process of a living cell in silico. This interdisciplinary endeavor marries systems biology, computational modeling, high-performance computing, and, increasingly, AI. All models are wrong, but some are alive. Somewhere in a data center right now, a virtual bacterium is dividing for the millionth time. Somewhere else, an AI-enhanced model is l

Topics: cell cells genes models virtual

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Virtual Cells

news.ycombinator.com Unknown 2025-08-30 23:18:38

Virtual cells Digital twins of biological cells—often referred to as virtual cells or whole-cell models (WCMs)–aim to recreate every relevant molecular process of a living cell in silico. This interdisciplinary endeavor marries systems biology, computational modeling, high-performance computing, and, increasingly, AI. All models are wrong, but some are alive. Somewhere in a data center right now, a virtual bacterium is dividing for the millionth time. Somewhere else, an AI-enhanced model is l

Topics: cell cells genes models virtual

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Toxic Proteins for Drug Discovery

news.ycombinator.com Asimov Press 2025-09-03 21:04:22

Noah Whiteman, professor of evolutionary biology at UC Berkeley, writes about how toxins are repurposed into medicines for Issue 06. Whiteman’s recent book is called “Most Delicious Poison.” Ella Watkins-Dulaney for Asimov Press. When you hear the word "poison," perhaps you picture a Victorian-era cobalt bottle labeled "NOT TO BE TAKEN" or the iconic pictogram of a leering skull and crossbones. What probably does not come to mind, however, are the dried white beans in your kitchen pantry, the

Topics: cells peptides proteins toxic toxin

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Sperm are very different from all other cells

news.ycombinator.com Unknown 2025-09-12 00:29:58

'There's a huge amount that we don't understand': Why sperm is still so mysterious 20 hours ago Share Save Katherine Latham Share Save How do sperm swim? How do they navigate? What is sperm made of? What does a World War Two codebreaker have to do with it all? The BBC untangles why we know so little about this mysterious cell. With every heartbeat, a man can produce around 1,000 sperm – and during intercourse, more than 50 million of the intrepid swimmers set out to fertilise an egg. Only a f

Topics: cells egg female says sperm

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Battery manufacturer Powin files for bankruptcy months after landing $200M loan

techcrunch.com Tim De Chant 2025-09-15 16:28:24

Battery manufacturer Powin filed for bankruptcy on Wednesday. The Oregon-based company said it has more than $300 million in debt. The Chapter 11 filing will let the company continue operating while it restructures its debt. Powin manufactured grid-scale batteries using lithium-iron-phosphate (LFP) cells from China. The company had been searching for alternative domestic suppliers, but the supply chain wasn’t sufficiently mature, Jeff Waters, the company’s former CEO, told Bloomberg in April.

Topics: cells company debt million powin

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Why Bats Don’t Get Cancer—and What That Means for Humans

gizmodo.com Margherita Bassi 2025-09-15 23:50:16

When you think of longevity in animals, chances are that the Greenland shark will immediately come up. After all, researchers estimate that the enigmatic animal can live for at least 250 years. It turns out, however, that bats also hold their own when it comes to lifespan, with some species living up to 25 years—equivalent to 180 human years—and they tend to do it cancer-free. Researchers from the University of Rochester (UR) have investigated anti-cancer “superpowers,” as described in a UR sta

Topics: bat bats cancer cells researchers

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Bats Have Cancer-Fighting ‘Superpowers’—Here’s What That Means for Humans

gizmodo.com Margherita Bassi 2025-09-16 04:50:16

When you think of longevity in animals, chances are that the Greenland shark will immediately come up. After all, researchers estimate that the enigmatic animal can live for at least 250 years. It turns out, however, that bats also hold their own when it comes to lifespan, with some species living up to 25 years—equivalent to 180 human years—and they tend to do it cancer-free. Researchers from the University of Rochester (UR) have investigated anti-cancer “superpowers,” as described in a UR sta

Topics: bat bats cancer cells researchers

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Latest Tech News

What's going on with gene therapies?

What's going on with gene therapies? (Part one)

A recap on May/June stability at Neon

A Recap on May/June Stability at Neon

GM’s Final EV Battery Strategy Copies China’s Playbook: Super Cheap Cells

GM to challenge China’s LFP monopoly with upgraded battery factory

Stem Cell Treatment to Reverse Hearing Loss Kicking Off in Human Patients

Mighty mitochondria: Cell powerhouses harnessed for healing

Making Explainable Minesweeper

Scientists Discover Secret Weapon That Allows Pythons to Digest Bones

At the frontier between two lives–the evolutionary origins of pregnancy

New Research Debunks Myth That Brain Cells Stop Growing After Childhood

Serenading Cells with Audible Sound Alters Gene Activity

Genetic code enables zebrafish to mend damaged organs

Biologists Uncover Previously Unknown Structure Hiding Inside Human Cells

Notorious Fungus Blamed for ‘Mummy’s Curse’ Is Now a Promising Cancer Treatment

New research links caffeine to slower aging at the cellular level

Now Google’s Gemini AI is ready to fill in those empty cells in your spreadsheet

Diabetic Woman No Longer Needs Insulin After Single Dose of Experimental Stem Cells

2048 with only 64 bits of state

Virtual cells

Virtual Cells

Toxic Proteins for Drug Discovery

Sperm are very different from all other cells

Battery manufacturer Powin files for bankruptcy months after landing $200M loan

Why Bats Don’t Get Cancer—and What That Means for Humans

Bats Have Cancer-Fighting ‘Superpowers’—Here’s What That Means for Humans

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