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What's going on with gene therapies?

news.ycombinator.com Nehal Udyavar 2025-07-20 01:48:53

Tree of Hope, Remain Strong (1946) by Frida Kahlo First attempts in a new field of medicine rarely go according to plan. On September 14, 1990, Dr. William French Anderson and his team at the National Institute of Health (NIH) performed the first official gene therapy trial. The patient, a 4-year-old Ashanti deSilva, suffered from a rare genetic disease called adenosine deaminase (ADA) deficiency, a form of severe combined immune deficiency (SCID). Children with ADA-SCID rarely make it to adult

Topics: cell cells gene months therapy

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What's going on with gene therapies? (Part one)

news.ycombinator.com Nehal Udyavar 2025-07-20 11:48:53

Tree of Hope, Remain Strong (1946) by Frida Kahlo First attempts in a new field of medicine rarely go according to plan. On September 14, 1990, Dr. William French Anderson and his team at the National Institute of Health (NIH) performed the first official gene therapy trial. The patient, a 4-year-old Ashanti deSilva, suffered from a rare genetic disease called adenosine deaminase (ADA) deficiency, a form of severe combined immune deficiency (SCID). Children with ADA-SCID rarely make it to adult

Topics: cell cells gene months therapy

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Another big car company gives up on hydrogen

engadget.com Unknown 2025-07-23 09:30:11

Stellantis, the automotive giant behind Chrysler, Citroen, Fiat, Jeep and Peugeot, is pulling out of hydrogen. The company said it’s killing its fuel cell development program in the face of “limited availability of hydrogen refueling infrastructure, high capital requirements and the need for stronger consumer purchasing incentives.” To put that another way, it’s realized hydrogen EVs are facing the same set of challenges it’s not been able to overcome in the last two or three decades. It’s a st

Topics: cell company energy fuel hydrogen

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A recap on May/June stability at Neon

news.ycombinator.com Nikita Shamgunov 2025-07-23 22:22:57

Details of incidents and what we did to prevent more in the future Starting in May, we had a series of feature launches with agentic AI partners that gained far more momentum than we predicted. In two short timespans, the rate of new database creation increased more than 5x, and the rate of branch creation increased more than 50x. While we were humbled by the uptick, the significant burst in operational load caused a lot of strain in the Neon platform, manifesting as more incidents over the cou

Topics: cells database databases incidents project

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A Recap on May/June Stability at Neon

news.ycombinator.com Nikita Shamgunov 2025-07-24 08:22:57

Details of incidents and what we did to prevent more in the future Starting in May, we had a series of feature launches with agentic AI partners that gained far more momentum than we predicted. In two short timespans, the rate of new database creation increased more than 5x, and the rate of branch creation increased more than 50x. While we were humbled by the uptick, the significant burst in operational load caused a lot of strain in the Neon platform, manifesting as more incidents over the cou

Topics: cells database databases incidents project

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High-resolution imaging method details nerves across a mouse’s body

news.ycombinator.com Lenharo 2025-07-24 19:14:51

The cranial nerves (blue) and blood vessels (red) in the head of a mouse are revealed by a high-resolution imaging technique. Credit: M.-Y. Shi et al./Cell (CC-BY-4.0) A speedy imaging method can map the nerves running from a mouse’s brain and spinal cord to the rest of its body at micrometre-scale resolution, revealing details such as individual fibres travelling from a key nerve to distant organs1. Previous efforts have mapped the network of connections between nerve cells, known as the conn

Topics: body brain cell mouse nerves

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T-Mobile’s US Cellular acquistion has been approved: What happened, and what’s next?

androidauthority.com Unknown 2025-07-26 18:41:18

Joe Maring / Android Authority TL;DR The DOJ and FCC have both approved T-Mobile’s $4.4 billion acquisition of most of US Cellular, with no major conditions or safeguards imposed. T-Mobile will gain US Cellular’s customers, stores, and spectrum, while US Cellular will keep its towers and focus on leasing them out. Critics worry the merger could reduce competition, especially in rural areas, but US Cellular customers shouldn’t see immediate changes at least. Last year, T-Mobile announced plan

Topics: cellular customers fcc mobile won

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GM’s Final EV Battery Strategy Copies China’s Playbook: Super Cheap Cells

wired.com John Voelcker 2025-07-29 21:21:12

General Motors has just announced its latest and likely final piece in what now appears to be a three-pronged cell-chemistry strategy to power GM’s lineup of a dozen EVs through the end of the decade and beyond. GM has stated today it will build low-cost lithium iron phosphate (LFP) battery cells in Spring Hill, Tennessee, starting in late 2027. Conversion of cell lines to produce that chemistry will begin later this year. The cell plant at the Spring Hill complex is owned and operated by Ultiu

Topics: cell cells chemistry gm lfp

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GM to challenge China’s LFP monopoly with upgraded battery factory

techcrunch.com Tim De Chant 2025-07-29 21:04:11

GM said Monday it is working with joint venture partner LG Energy Solution to upgrade its Ultium battery factory to make lithium-iron-phosphate cells for the automaker’s low-cost EVs. The factory’s overhaul will give LFP production in the United States a significant boost. Despite being invented and commercialized in the U.S., today the vast majority of LFP cells are currently made in China. The $2.3 billion Spring Hill, Tennessee, battery plant is part of the Ultium Cells LLC joint venture be

Topics: battery cells chemistry gm lfp

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Stem Cell Treatment to Reverse Hearing Loss Kicking Off in Human Patients

futurism.com Unknown 2025-07-30 10:15:43

Image by Getty / Futurism Developments The first-ever human trial exploring the use of stem cell therapy to reverse hearing loss is about to be under way, after getting the go-ahead from the UK’s Medicines and Healthcare products Regulatory Agency. Conducted by researchers from the University of Sheffield who formed their own spin-out company, the treatment targets sensorineural hearing loss, which is caused by physical damage to the tiny structures of the inner ear. In a nutshell, the treatm

Topics: cells ear hearing inner stem

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Trump’s DOJ seems annoyed about having to approve T-Mobile’s latest merger

arstechnica.com Unknown 2025-07-31 17:52:23

The Department of Justice Antitrust Division issued an unusual statement yesterday about its decision to let T-Mobile complete an acquisition of US Cellular's wireless operations. Assistant Attorney General Gail Slater of the Justice Department's Antitrust Division, a Trump nominee who was confirmed by the Senate in March, said in a 900-word statement that the deal and two related transactions "will consolidate yet more spectrum in the Big 3's oligopoly, which controls more than 80 percent of t

Topics: cellular mobile said spectrum wireless

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Mighty mitochondria: Cell powerhouses harnessed for healing

arstechnica.com Unknown 2025-08-04 06:10:31

James McCully was in the lab extracting tiny structures called mitochondria from cells when researchers on his team rushed in. They’d been operating on a pig heart and couldn’t get it pumping normally again. McCully studies heart damage prevention at Boston Children’s Hospital and Harvard Medical School and was keenly interested in mitochondria. These power-producing organelles are particularly important for organs like the heart that have high energy needs. McCully had been wondering whether t

Topics: cells damage heart mccully mitochondria

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Making Explainable Minesweeper

news.ycombinator.com Unknown 2025-08-01 09:56:04

🎮Game 🧩Puzzle 💣Minesweeper 🤖Algorithm 💻Game Dev Background I recently purchased and played a game called 14 Minesweeper Variants during a Steam Summer sale. It was a fun game. However, I became curious while looking at the hints provided in the game. What exactly are these? Actually, when I played Minesweeper, which was a default Windows game, I could solve cases where there was a definite answer, but I remember stepping on countless mines in ambiguous situations. For example, situations like

Topics: area cells deduction game mines

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ANC Nothing Earbuds With ChatGPT Integration Cost Nothing for Prime Day, Lowest Price Since Launch

gizmodo.com Joe Tilleli 2025-08-05 09:50:36

Every single person has a reason why they’d benefit from owning a pair of noise-cancelling headphones or earbuds. Riding the subway, turning off the world around you while listening to the newest Sabrina Carpenter album. Sitting at your desk at work, crunching some numbers while catching up on your favorite podcast breaking down the discourse surrounding the newest Sabrina Carpenter album. For Prime Day, Nothing’s noise-cancelling earbuds with ChatGPT integration has been chopped down by 37%. Th

Topics: able cancelling earbuds just noise

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Apple AirPods Max Have Never Been This Cheap, Even Compared to Black Friday, Thanks to Prime Day

gizmodo.com Brittany Vincent 2025-08-05 21:50:49

There’s a certain kind of listening experience that sticks with you. It’s the moment a favorite song sounds clearer, fuller, more alive than it ever has before. You know you’re listening to a tune or album that you’ve heard before, but something about it hits much, much harder than usual. That kind of moment is what the AirPods Max were built for. And if you’re looking to try a pair, now’s a good time to buy them now that they’re on sale for Prime Day. ‘ Run to Amazon Prime deal now to get the

Topics: airpods cancellation feel listening max

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Apple Didn’t Approve, but Amazon Clears Out AirPods Pro 2 at a Record Low for Prime Day

gizmodo.com Gizmodo Deals 2025-08-06 01:41:07

AirPods Pro 2 are in stores just a year but already they set the benchmark by which other wireless earbuds with active noise cancellation are judged. On the subject of sound quality, nothing else comes close to holding a candle right now. Normally these earbuds cost $249, but Amazon is offering them over 40% off during Prime Day, reducing the price to as low as $149. This deal is for everyone (and not just Prime members) and it is a rarity for an Apple device. Remember, Apple never really offer

Topics: active apple cancellation earbuds noise

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Scientists Discover Secret Weapon That Allows Pythons to Digest Bones

gizmodo.com Ellyn Lapointe 2025-08-06 15:00:40

Pythons are notorious for their eating habits. After suffocating their prey with their lithe bodies, these large snakes swallow the animal whole. Now, researchers have shed new light on the cellular mechanisms that allow them to digest entire skeletons. The study, presented July 9 at the Society for Experimental Biology Annual Conference in Belgium and published in the Journal of Experimental Biology, investigated the intestinal cells of Burmese pythons. Adult males can grow to be 10 to 16 feet

Topics: calcium cells particles pythons snakes

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At the frontier between two lives–the evolutionary origins of pregnancy

news.ycombinator.com University Of Vienna 2025-08-04 05:17:47

This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility: Single-cell transcriptomic atlases of six mammalian species spanning the diversification of viviparity. Credit: Nature Ecology & Evolution (2025). DOI: 10.1038/s41559-025-02748-x An international research team led by scientists from the University of Vienna has uncovered new insights into how specialized cell types

Topics: cell cells evolution fetus maternal

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DOJ Releases Video of Jeffrey Epstein’s Jail Cell, but There’s a Minute Missing

gizmodo.com Matt Novak 2025-08-08 13:25:51

The U.S. Department of Justice has released video from the jail in New York where Jeffrey Epstein was held, recorded the day he died in 2019. The release is part of a campaign by the Trump regime to convince skeptical Americans that the child sex offender really did kill himself. But the video is only creating more conspiracy theories because there appears to be about one minute missing. The video released by DOJ, from inside the Metropolitan Correctional Center, begins at 7:30 p.m. on August 9

Topics: cell doj epstein released video

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The Best Way to Stop Mosquitos Isn't a Spray or Candle, and It's 13% Off for Amazon Prime Day

cnet.com See Full Bio 2025-08-08 20:25:00

Amazon Prime Day Deal: The Thermacell E-Series mosquito repellant system keeps bugs 20 feet away, and it's $5 off (that's a 13% price drop) for Amazon Prime Day right now. The main unit stands about 5 inches tall and holds a 6.5-hour charge while dispensing a DEET-free repellant. Longer, hotter summers mean one thing: longer, itchier, angrier mosquito seasons. And if June's sizzling heat waves are any preview of summer's dog days, you're gonna need more than good vibes and a flickering citronel

Topics: 20 bug mosquito summer thermacell

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AirPods Pro 3 are coming, and rumored to have my top feature request

9to5mac.com Ryan Christoffel 2025-08-10 13:10:54

AirPods Pro 3 are in active development, and even though the release timing is still unclear, there’s been one rumored feature in particular that I’m especially excited about: improved active noise cancellation. Noise cancellation has long been a critical AirPods Pro feature for me I’ve been an AirPods user since the first model was introduced alongside the iPhone 7 in 2017. But when AirPods Pro debuted, I was immediately sold. Several features were appealing to me, but one standout was the i

Topics: airpods cancellation feature noise pro

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Apple Didn’t Approve, but Amazon Is Clearing Out AirPods Pro 2 at a Record Low for Prime Day

gizmodo.com Gizmodo Deals 2025-08-11 01:52:07

AirPods Pro 2 are in stores just a year but already they set the benchmark by which other wireless earbuds with active noise cancellation are judged. On the subject of sound quality, nothing else comes close to holding a candle right now. Normally these earbuds cost $249, but Amazon is offering them over 30% off early Prime Day, reducing the price to as low as $169. This deal is for everyone (and not just Prime members) and it is a rarity for an Apple device. Remember, Apple never really offers

Topics: active apple cancellation earbuds noise

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Why government red tape is draining your phone’s battery potential

androidauthority.com Unknown 2025-08-10 20:00:15

Robert Triggs / Android Authority You’re not alone if you’re pining for longer battery life from your latest smartphone. Despite emerging technologies like silicon-carbon cells, we’ve seemingly hit a ceiling just above the 5,000 mAh mark — at least for phones sold in the US and Europe. Meanwhile, glance over at models in China or India, and you’ll spot far larger batteries in otherwise identical handsets. For example, the new Nothing Phone 3 packs a 5,150mAh battery globally, but bumps that up

Topics: batteries battery cell regulations rules

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Ready-made stem cell therapies for pets could be coming

techcrunch.com Connie Loizos 2025-08-11 01:36:00

Earlier this week, San Diego startup Gallant announced $18 million in funding to bring the first FDA-approved ready-to-use stem cell therapy to veterinary medicine. If it passes regulatory muster, it could create a whole new way to treat our fur babies. It’s still an experimental field, even though people have been researching stem cells for humans for decades. Seven-year-old Gallant’s first target is a painful mouth condition in cats called Feline Chronic Gingivostomatitis (FCGS), which Gallan

Topics: cell fda gallant stem therapy

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The best earbuds we’ve tested for 2025

theverge.com Chris Welch 2025-08-12 05:00:00

is a former senior reviewer who worked at The Verge from 2011 until May 2025. His coverage areas included audio (Sonos, Apple, Bose, Sony, etc.), home theater, smartphones, photography, and more. Editor’s note: Amazon Prime Day kicks off on July 8th; however, if you want to get a head start on your online shopping, we’ve rounded up the best early Prime Day deals you can already get. It’s hard to buy a bad pair of wireless earbuds these days, and with constant discounts and deals wherever you l

Topics: best cancellation earbuds noise pro

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New Research Debunks Myth That Brain Cells Stop Growing After Childhood

gizmodo.com Ed Cara 2025-08-14 05:00:50

You’ve probably heard the old canard that new brain cells simply stop forming as we become adults. But research out today is the latest to show that this isn’t really true. Scientists in Sweden led the study, published Thursday in Science. They found abundant signs of neural stem cells growing in the hippocampus of adult brains. The findings reveal more about the human brain as we get older, the researchers say, and also hint at potential new ways to treat neurological disorders. “We’ve found

Topics: adult brain cells neurogenesis new

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CBP Wants New Tech to Search for Hidden Data on Seized Phones

wired.com Caroline Haskins 2025-08-14 09:19:59

United States Customs and Border Protection (CBP) is asking tech companies to pitch digital forensics tools that are designed to process and analyze text messages, pictures, videos, and contacts from seized phones, laptops, and other devices at the United States border, according to documents reviewed by WIRED. The agency said in a federal registry listing that the tools it’s seeking must have very specific capabilities, such as the ability to find a “hidden language” in a person’s text message

Topics: cbp cellebrite devices messages tools

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Serenading Cells with Audible Sound Alters Gene Activity

news.ycombinator.com Simon Makin 2025-08-12 19:04:53

The cells in your ears aren’t the only ones listening: recent research suggests that crucial cells throughout the body may respond to audible sound. Experiments described in Communications Biology revealed more than 100 genes whose activity changed in response to these acoustic waves, pointing to possible medical applications. Extensive earlier research has shown that ultrasound—sound at frequencies higher than humans can hear—can affect biology in numerous ways; the new study expands this conc

Topics: activity audible cells genes sound

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I Found the Best Way to Stop Mosquitos This Summer, and It's Not a Spray or Candle

cnet.com See Full Bio 2025-08-17 07:51:00

Longer, hotter summers mean one thing: longer, itchier, angrier mosquito seasons. And if June's sizzling heat waves are any preview of summer's dog days, you're gonna need more than good vibes and a flickering citronella candle to make it through. I was playing it fast and loose with the usual bug defenses: sprays that smell bad and taste even worse and candles that burn out faster than your will to be outside. Then I met my new summer MVP: the Thermacell. It's a compact, affordable, bug-repell

Topics: bug mosquito summer testing thermacell

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Genetic code enables zebrafish to mend damaged organs

news.ycombinator.com Unknown 2025-08-18 01:00:11

Zebrafish have the remarkable and rare ability to regrow and repair their hearts after damage. New research from Caltech and UC Berkeley has identified the circuit of genes controlling this ability and offers clues about how a human heart might someday be repaired after damage, such as a heart attack or in cases of congenital heart defects. The research was a collaboration between the laboratories of Marianne Bronner, Caltech's Edward B. Lewis Professor of Biology and director of the Beckman In

Topics: cells crest genes heart neural

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Latest Tech News

What's going on with gene therapies?

What's going on with gene therapies? (Part one)

Another big car company gives up on hydrogen

A recap on May/June stability at Neon

A Recap on May/June Stability at Neon

High-resolution imaging method details nerves across a mouse’s body

T-Mobile’s US Cellular acquistion has been approved: What happened, and what’s next?

GM’s Final EV Battery Strategy Copies China’s Playbook: Super Cheap Cells

GM to challenge China’s LFP monopoly with upgraded battery factory

Stem Cell Treatment to Reverse Hearing Loss Kicking Off in Human Patients

Trump’s DOJ seems annoyed about having to approve T-Mobile’s latest merger

Mighty mitochondria: Cell powerhouses harnessed for healing

Making Explainable Minesweeper

ANC Nothing Earbuds With ChatGPT Integration Cost Nothing for Prime Day, Lowest Price Since Launch

Apple AirPods Max Have Never Been This Cheap, Even Compared to Black Friday, Thanks to Prime Day

Apple Didn’t Approve, but Amazon Clears Out AirPods Pro 2 at a Record Low for Prime Day

Scientists Discover Secret Weapon That Allows Pythons to Digest Bones

At the frontier between two lives–the evolutionary origins of pregnancy

DOJ Releases Video of Jeffrey Epstein’s Jail Cell, but There’s a Minute Missing

The Best Way to Stop Mosquitos Isn't a Spray or Candle, and It's 13% Off for Amazon Prime Day

AirPods Pro 3 are coming, and rumored to have my top feature request

Apple Didn’t Approve, but Amazon Is Clearing Out AirPods Pro 2 at a Record Low for Prime Day

Why government red tape is draining your phone’s battery potential

Ready-made stem cell therapies for pets could be coming

The best earbuds we’ve tested for 2025

New Research Debunks Myth That Brain Cells Stop Growing After Childhood

CBP Wants New Tech to Search for Hidden Data on Seized Phones

Serenading Cells with Audible Sound Alters Gene Activity

I Found the Best Way to Stop Mosquitos This Summer, and It's Not a Spray or Candle

Genetic code enables zebrafish to mend damaged organs

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