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Cancer DNA is detectable in blood years before diagnosis

Cancer’s genetic fingerprints may lurk in people’s blood long before they find out about the disease. It’s possible to spot tumor DNA more than three years before a person is diagnosed with cancer, researchers report May 22 in Cancer Discovery. “We were shocked that we could find DNA,” says Yuxuan Wang, an oncologist and cancer researcher at Johns Hopkins University School of Medicine. The findings suggest that hunting for these telltale traces using highly sensitive and accurate technology co

A brief history of “three-parent babies”

I can’t go any further without talking about the term we use to describe these children. Journalists, myself included, have called them “three-parent babies” because they are created using DNA from three people. Briefly, the approach typically involves using the DNA from the nuclei of the intended parents’ egg and sperm cells. That’s where most of the DNA in a cell is found. But it also makes use of mitochondrial DNA (mtDNA)—the DNA found in the energy-producing organelles of a cell—from a thir

The Download: three-person babies, and tracking “AI readiness” in the US

Eight babies have been born in the UK thanks to a technology that uses DNA from three people: the two biological parents plus a third person who supplies healthy mitochondrial DNA. The babies were born to mothers who carry genes for mitochondrial diseases and risked passing on severe disorders. In the team’s approach, patients’ eggs are fertilized with sperm, and the DNA-containing nuclei of those cells are transferred into donated fertilized eggs that have had their own nuclei removed. The new

8 Healthy ‘Three-Parent’ Babies Born in UK Using Pioneering IVF Technique

So-called “three-parent” babies are thriving in the U.K. New clinical trial research shows that several healthy children in the country have been born with the DNA of three people. Doctors at Newcastle University led the study, which involved around two dozen women with a high risk of passing down harmful mutations of their mitochondria to their children. So far, eight kids have been born using an in vitro fertilization (IVF) technique that replaces a mother’s damaged mitochondrial DNA with tha

Researchers announce babies born from a trial of three-person IVF

The study, which makes use of a technology called mitochondrial donation, has been described as a “tour de force” and “a remarkable accomplishment” by others in the field. In the team’s approach, patients’ eggs are fertilized with sperm, and the DNA-containing nuclei of those cells are transferred into donated fertilized eggs that have had their own nuclei removed. The new embryos contain the DNA of the intended parents along with a tiny fraction of mitochondrial DNA from the donor, floating in

DHS Faces New Pressure Over DNA Taken From Immigrant Children

United States Senator Ron Wyden is pressing the United States departments of Homeland Security and Justice to explain how and why they are collecting DNA from immigrants, including children, on a massive scale. Wyden confronted the agencies with demands this week to explain the scope, legality, and oversight of the government’s DNA collection. In letters to DOJ and DHS, the Oregon Democrat also criticized what he described as a “chilling expansion” of a sprawling and opaque system, accusing Tru

Large-scale DNA study maps 37,000 years of human disease history

A new study suggests that our ancestors’ close cohabitation with domesticated animals and large-scale migrations played a key role in the spread of infectious diseases. The team, led by Professor Eske Willerslev at the Universities of Cambridge and Copenhagen, recovered ancient DNA from 214 known human pathogens in prehistoric humans from Eurasia. They found that the earliest evidence of zoonotic diseases – illnesses transmitted from animals to humans, like COVID in recent times – dates back t

Scientists Finally Sequenced the First Ancient Egyptian Genome

Scientists have, for the first time, sequenced the entire genome of an ancient Egyptian who lived approximately 4,500 to 4,800 years ago. The feat was achieved by a team of researchers at the Francis Crick Institute and Liverpool John Moores University, who published their findings in Nature. According to the study, the ancient individual’s genetic ancestry traces back to populations in both North Africa and West Asia, shedding light on the genetic diversity of early Egyptians. Researchers fir

Ancient DNA Unlocks the Secret Recipe of Roman Fish Sauce

Ancient Romans were known for creating delicious sauces, including garum—a famous fish-based condiment. Scientists studying ancient DNA from a Roman-era salting plant in Spain have found that European sardines were the key ingredient. Fish was an important part of the ancient Roman diet, and Romans processed their catch for long-term preservation in coastal fish-salting plants called cetariae. There, they crushed and fermented small fish into pastes and sauces such as the iconic umami-flavored

Experimental Propulsion Tech Could Reach Mysterious Planet Beyond Pluto in 10 Years

On November 14, 2003, astronomers spotted what was at the time the most distant known object orbiting the Sun. They called it Sedna after the Inuit goddess of the ocean. It’s a cold, reddish dwarf planet that drifts billions of miles away from the Sun during its 10,000-year orbit before coming in for a relatively close approach to our star. Its next perihelion is happening in July 2076, and astronomers want to take advantage of this rare encounter by flying a mission to the mysterious object. A

AlphaGenome: AI for Better Understanding the Genome

Science AlphaGenome: AI for better understanding the genome Share Copy link × Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API. The genome is our cellular instruction manual. It’s the complete set of DNA which guides nearly every part of a living organism, from appearance and function to growth and reproduction. Small variations in a genome’s DNA sequence can alter a

AlphaGenome: AI for better understanding the genome

Science AlphaGenome: AI for better understanding the genome Share Copy link × Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API. The genome is our cellular instruction manual. It’s the complete set of DNA which guides nearly every part of a living organism, from appearance and function to growth and reproduction. Small variations in a genome’s DNA sequence can alter a

Google DeepMind Releases AlphaGenome

Science AlphaGenome: AI for better understanding the genome Share Copy link × Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API. The genome is our cellular instruction manual. It’s the complete set of DNA which guides nearly every part of a living organism, from appearance and function to growth and reproduction. Small variations in a genome’s DNA sequence can alter a

The Download: Google DeepMind’s DNA AI, and heatwaves’ impact on the grid

When scientists first sequenced the human genome in 2003, they revealed the full set of DNA instructions that make a person. But we still didn’t know what all those 3 billion genetic letters actually do. Now Google’s DeepMind division says it’s made a leap in trying to understand the code with AlphaGenome, an AI model that predicts what effects small changes in DNA will have on an array of molecular processes, such as whether a gene’s activity will go up or down. It’s just the sort of ques

Researchers get viable mice by editing DNA from two sperm

For many species, producing an embryo is a bit of a contest between males and females. Males want as many offspring as possible, and want the females to devote as many resources as possible to each of them. Females are better at keeping their options open and distributing resources in a way to maximize the number of offspring they can produce over the course of their lives. In mammals, this plays out through the chemical modification of DNA, a process called imprinting. Males imprint their DNA

We’ve had a Denisovan skull since the 1930s—only nobody knew

A 146,000-year-old skull from Harbin, China, belongs to a Denisovan, according to a recent study of proteins preserved inside the ancient bone. The paleoanthropologists who studied the Harbin skull in 2021 declared it a new (to us) species, Homo longi. But the Harbin skull still contains enough of its original proteins to tell a different story: A few of them matched specific proteins from Denisovan bones and teeth, as encoded in Denisovan DNA. So Homo longi was a Denisovan all along, and thank

You Can Now Buy a Sample of Ozzy Osbourne's DNA in Twelve Easy Payments

A kitschy new brand partnership between John "Ozzy" Osbourne and Liquid Death, the canned water brand, is releasing a limited run of cans of iced tea infused with DNA from the Prince of Darkness himself. Sadly, the iced tea is long gone. The cans have all been chugged and crushed by Osbourne himself, leaving "behind trace DNA from his saliva that you can now own," according to Liquid Death's website. But let's be real, you don't buy a rockstar's backwash to quench your thirst — you're buying i

AMD's next-gen UDNA graphics cards will support up to 80 Gbps HDMI 2.2 connectivity

Something to look forward to: AMD has reportedly been working on its next-generation GPU architecture for at least two years. The new architecture will be called UDNA, replacing the RDNA name, and is expected to deliver significantly faster performance than RDNA 4. A tipster has now shared details about the rumored HDMI configuration of the first-generation UDNA GPUs. According to Kepler_L2, UDNA GPUs – codenamed GFX13 – will support 64 Gbps and 80 Gbps bandwidths over HDMI 2.2 connections. If

Topics: amd gbps gpus hdmi udna

DNA floating in the air tracks wildlife, viruses, even drugs

Dublin is known as a city where you can enjoy a few pints of Guiness, get a warm welcome from the locals and hear lively traditional music drifting out of pubs and into the city air. But it's not just music floating on the breeze. The air of Dublin also contains cannabis, poppy, even magic mushrooms -- at least their DNA. That's according to a new study that reveals the power of DNA, vacuumed up from the air, which can track everything from elusive bobcats to illicit drugs. "The level of info

Researchers are now vacuuming DNA from the air

Dublin is known as a city where you can enjoy a few pints of Guiness, get a warm welcome from the locals and hear lively traditional music drifting out of pubs and into the city air. But it's not just music floating on the breeze. The air of Dublin also contains cannabis, poppy, even magic mushrooms -- at least their DNA. That's according to a new study that reveals the power of DNA, vacuumed up from the air, which can track everything from elusive bobcats to illicit drugs. "The level of info

Modder runs AMD FSR 4 on unsupported Radeon 7000 series GPUs, performance lags behind FSR 3.1

Serving tech enthusiasts for over 25 years.TechSpot means tech analysis and advice you can trust In brief: AMD's new FSR 4 upscaling solution improves tremendously upon FSR 3 but only supports the company's Radeon RX 9070 and 9060 graphics card families. However, the latest version of Mesa for Linux provides a loophole that allowed a modder to benchmark FSR 4 on an older GPU, with intriguing results. Redditor Virtual-Cobbler-9930 recently shared encouraging data after testing AMD's FSR 4 on a

A Visual Guide to Genome Editors

It was Victoria Gray’s first time in London and, despite a sleepless plane ride across the Atlantic Ocean, she wasn’t about to skip sightseeing. While crossing Trafalgar Square, Gray paused briefly to reflect on her experience. “I would never have been able to walk this long before,” she told a NPR reporter. “I feel like I got a second chance.” Four years earlier, in 2019, Gray had become the first patient with sickle cell anemia — a genetic disorder that causes red blood cells to become sticky

We’ve had a Denisovan skull since the 1930s—only nobody knew

A 146,000-year-old skull from Harbin, China, belongs to a Denisovan, according to a recent study of proteins preserved inside the ancient bone. The paleoanthropologists who studied the Harbin skull in 2021 declared it a new (to us) species, Homo longi. But the Harbin skull still contains enough of its original proteins to tell a different story: A few of them matched specific proteins from Denisovan bones and teeth, as encoded in Denisovan DNA. So Homo longi was a Denisovan all along, and thank

AMD's CDNA 4 Architecture Announcement

CDNA 4 is AMD’s latest compute oriented GPU architecture, and represents a modest update over CDNA 3. CDNA 4’s focus is primarily on boosting AMD’s matrix multiplication performance with lower precision data types. Those operations are important for machine learning workloads, which can often maintain acceptable accuracy with very low precision types. At the same time, CDNA 4 seeks to maintain AMD’s lead in more widely applicable vector operations. To do so, CDNA 4 largely uses the same system

Topics: amd cdna data lds nvidia

AMD's CDNA 4 Architecture Announcement – By Chester Lam

CDNA 4 is AMD’s latest compute oriented GPU architecture, and represents a modest update over CDNA 3. CDNA 4’s focus is primarily on boosting AMD’s matrix multiplication performance with lower precision data types. Those operations are important for machine learning workloads, which can often maintain acceptable accuracy with very low precision types. At the same time, CDNA 4 seeks to maintain AMD’s lead in more widely applicable vector operations. To do so, CDNA 4 largely uses the same system

Topics: amd cdna data lds nvidia