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Tiny microbe challenges the definition of cellular life

Scientists recently discovered a microbe with one of the tiniest genomes on Earth. More surprising, the creature is almost entirely dependent on its host: Its genes don’t support any of the functions of metabolism, one of the key processes of life. As such, it challenges fundamental notions of what it means to be a living organism. The discovery was “pure serendipity,” says Takuro Nakayama, an evolutionary microbiologist at the University of Tsukuba in Japan. Takayama wanted to study the many m

Hibernation’s Hidden Healing ‘Superpowers’ Could Be Locked in Our DNA

After spending months without eating, drinking, or moving, hibernating mammals must rebound from extreme physiological changes. Two new studies suggest that the genetic “superpowers” underlying this incredible resilience may also be present in the human genome. For these studies, published Thursday, July 31, in the journal Science, researchers at the University of Utah honed in on the specific DNA regions that help hibernators rapidly recover from muscle atrophy, insulin resistance, and brain d

Scientists Find Secret Code in Human DNA

Image by Getty / Futurism Genetics One person's junk is another's treasure. An international team of scientists have found that strings of "junk" DNA in the human genome that were previously written off as having no useful function are actually pretty important after all. The work, published as a study in the journal Science Advances, focuses on transposable elements, a class of DNA sequences that can "jump," via a biological copy-and-paste mechanism, to different locations in a genome. These

Whole-genome ancestry of an Old Kingdom Egyptian

Provenance and ethics The human remains were excavated from the Nuwayrat necropolis near Beni Hasan, Egypt. They were donated between 1902 and 1904 by the Egyptian Antiquities Service to the members of the Beni Hasan excavation committee and subsequently donated to the Institute of Archaeology, University of Liverpool and exported under the John Garstang export permit. The human remains were then donated to the World Museum (previously the Liverpool City Museum) in 1950. Sampling permit was gra

Scientists Playing God are Building Human DNA From the Ground Up

Image by Getty / Futurism Studies Biological science has made such astonishing leaps in the last few decades, such as precise gene editing, that scientists are now tackling the next logical — yet inherently controversial — step: fabricating human DNA from the ground up. Details are a bit vague, but a team of scientists in the United Kingdom have embarked on a new project to construct what they describe in a statement as the "first synthetic human chromosome." The scientists hope that the five

Scientists Launch Wild New Project to Build a Human Genome From Scratch

A team of UK-based researchers is going where no scientist has dared to go—writing artificial human DNA from scratch. They’re hoping the project will answer fundamental questions about the human genome and transform our understanding of health and disease. But the research topic is, for obvious reasons, controversial. Scientists have largely steered clear of trying to create full synthetic human genomes, wary of propelling us into a dystopian, Gattaca-esque future full of designer babies. Now,

AlphaGenome: AI for Better Understanding the Genome

Science AlphaGenome: AI for better understanding the genome Share Copy link × Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API. The genome is our cellular instruction manual. It’s the complete set of DNA which guides nearly every part of a living organism, from appearance and function to growth and reproduction. Small variations in a genome’s DNA sequence can alter a

AlphaGenome: AI for better understanding the genome

Science AlphaGenome: AI for better understanding the genome Share Copy link × Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API. The genome is our cellular instruction manual. It’s the complete set of DNA which guides nearly every part of a living organism, from appearance and function to growth and reproduction. Small variations in a genome’s DNA sequence can alter a

Google DeepMind Releases AlphaGenome

Science AlphaGenome: AI for better understanding the genome Share Copy link × Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API. The genome is our cellular instruction manual. It’s the complete set of DNA which guides nearly every part of a living organism, from appearance and function to growth and reproduction. Small variations in a genome’s DNA sequence can alter a

Google’s new AI will help researchers understand how our genes work

“We haven’t designed or validated AlphaGenome for personal genome prediction, a known challenge for AI models,” Google said in a statement. Underlying the AI system is the so-called transformer architecture invented at Google that also powers large language models like GPT-4. This one was trained on troves of experimental data produced by public scientific projects. Lareau says the system will not broadly change how his lab works day to day but could permit new types of research. For instance,

Researchers get viable mice by editing DNA from two sperm

For many species, producing an embryo is a bit of a contest between males and females. Males want as many offspring as possible, and want the females to devote as many resources as possible to each of them. Females are better at keeping their options open and distributing resources in a way to maximize the number of offspring they can produce over the course of their lives. In mammals, this plays out through the chemical modification of DNA, a process called imprinting. Males imprint their DNA