Published on: 2025-06-07 08:51:58
This post was last updated in September 2024. I can’t promise this will be up-to-date when you come across it. Whether you believe in preventing damage (the core aim of the aging field - though that's not the focus of this post) or treating damage as it arises, our current best efforts in both treatment and mechanism selection haven’t yielded promising results. None of the approved drugs for age-related diseases reverse any damage. They don't even halt disease progression. The primary endpoints
Keywords: approved disease drugs mash treatment
Find related items on AmazonPublished on: 2025-07-04 19:34:09
Image by Getty / Futurism Treatments Scientists used CRISPR tech to create a custom-made drug targeted at helping a newborn baby fight a rare genetic disorder. According to an extraordinary new paper published in The New England Journal of Medicine, the drug worked — marking the first time that a patient was successfully healed with a bespoke gene-hacked medicine, and a possible watershed moment for the field of genetic medicine. The baby, named KJ Muldoon, was born at the Children's Hospital
Keywords: drug genetic kj liver treatment
Find related items on AmazonPublished on: 2025-07-05 03:00:23
In the boy's fourth month, researchers were meeting with the Food and Drug Administration to discuss regulatory approval for a clinical trial—a trial where KJ would be the only participant. They were also working with the institutional review board (IRB) at Children’s Hospital of Philadelphia to go over the clinical protocol, safety, and ethical aspects of the treatment. The researchers described the unprecedented speed of the oversight steps as being "through alternative procedures." In month
Keywords: kj month researchers therapy treatment
Find related items on AmazonPublished on: 2025-07-05 08:00:23
In the boy's fourth month, researchers were meeting with the Food and Drug Administration to discuss regulatory approval for a clinical trial—a trial where KJ would be the only participant. They were also working with the institutional review board (IRB) at Children’s Hospital of Philadelphia to go over the clinical protocol, safety, and ethical aspects of the treatment. The researchers described the unprecedented speed of the oversight steps as being "through alternative procedures." In month
Keywords: kj month researchers therapy treatment
Find related items on AmazonPublished on: 2025-07-06 08:10:00
Doctors say they constructed a bespoke gene-editing treatment in less than seven months and used it to treat a baby with a deadly metabolic condition. The rapid-fire attempt to rewrite the child’s DNA marks the first time gene editing has been tailored to treat a single individual. The baby who was treated, Kyle “KJ” Muldoon Jr., suffers from a rare metabolic condition caused by a particularly unusual gene misspelling. Researchers say their attempt to correct the error demonstrates the high l
Keywords: drugs editing experimental gene treatments
Find related items on AmazonPublished on: 2025-07-07 06:06:06
Instead, KJ has made medical history. The baby, now 9 ½ months old, became the first patient of any age to have a custom gene-editing treatment, according to his doctors. He received an infusion made just for him and designed to fix his precise mutation. The investigators who led the effort to save KJ are presenting their work on Thursday at the annual meeting of the American Society of Cell & Gene Therapy, and are also publishing it in the New England Journal of Medicine. The implications of
Keywords: gene kj new therapy treatment
Find related items on AmazonPublished on: 2025-07-07 11:06:06
Instead, KJ has made medical history. The baby, now 9 ½ months old, became the first patient of any age to have a custom gene-editing treatment, according to his doctors. He received an infusion made just for him and designed to fix his precise mutation. The investigators who led the effort to save KJ are presenting their work on Thursday at the annual meeting of the American Society of Cell & Gene Therapy, and are also publishing it in the New England Journal of Medicine. The implications of
Keywords: gene kj new therapy treatment
Find related items on AmazonPublished on: 2025-07-07 20:00:00
Last August, KJ Muldoon was born with a potentially fatal genetic disorder. Just six months later, he received a Crispr treatment designed just for him. Muldoon has a rare disorder known as CPS1 deficiency, which causes a dangerous amount of ammonia to build up in the blood. About half of babies born with it will die early in life. Current treatment options—a highly restrictive diet and liver transplantation—aren’t ideal. But a team at the Children’s Hospital of Philadelphia and Penn Medicine w
Keywords: ammonia crispr gene kj treatment
Find related items on AmazonPublished on: 2025-07-09 16:45:13
Montana is set to become a proving ground for experimental medical treatments, thanks to a newly passed bill. The bill, signed into law by Governor Greg Gianforte this week, will permit clinics and doctors to sell and provide nearly any experimental drug to potential patients, so long as it has undergone at least one Phase I clinical trial. Advocates argue that the law will allow Montana to be a hub for medical tourism, especially for potentially life-extending medicine, while some bioethicists
Keywords: drug drugs experimental law treatments
Find related items on AmazonPublished on: 2025-07-15 12:54:34
In 2012, clinicians at the Children’s Hospital of Philadelphia treated Emily Whitehead, a 6-year-old with leukemia, with altered immune cells from her own body. At the time, the treatment was experimental, but it worked: The cells targeted the cancer and eradicated it. Thirteen years later, Whitehead is still cancer-free. The modified cells, called CAR-T cells, are a form of immunotherapy, where doctors change parts of the immune system into cancer-attacking instruments. About five years after
Keywords: cancer car cells treatment whitehead
Find related items on AmazonPublished on: 2025-07-22 18:38:44
Lyme disease, a disease transmitted when deer ticks feed on infected animals like deer and rodents, and then bite humans, impacts nearly half a million individuals in the U.S. annually. Lyme can be devastating; but early treatment with antibiotics can prevent chronic symptoms like heart and neurological problems and arthritis from developing. What’s new In two new studies led by bacteriologist Brandon L. Jutras, Northwestern scientists have identified an antibiotic that cures Lyme disease at a
Keywords: bacteria disease jutras lyme treatment
Find related items on AmazonPublished on: 2025-07-24 10:38:44
Lyme disease, a disease transmitted when deer ticks feed on infected animals like deer and rodents, and then bite humans, impacts nearly half a million individuals in the U.S. annually. Lyme can be devastating; but early treatment with antibiotics can prevent chronic symptoms like heart and neurological problems and arthritis from developing. What’s new In two new studies led by bacteriologist Brandon L. Jutras, Northwestern scientists have identified an antibiotic that cures Lyme disease at a
Keywords: bacteria disease jutras lyme treatment
Find related items on AmazonPublished on: 2025-07-30 00:16:48
Johnny Appleseed used to be a staple character in old American children’s books. A ragged vagabond in the early nineteenth century, Appleseed traveled barefoot through the forest, wore coffee sacks with cut-out holes for his arms and head, and planted thousands upon thousands of apple trees for the first settlers in Pennsylvania, Ohio, Illinois, and Indiana. From the Special Series: How the System Works “Appleseed” was a nickname; he was born as John Chapman. As a young man, Chapman became con
Keywords: city sewage systems treatment water
Find related items on AmazonPublished on: 2025-08-15 12:01:01
About Recover Recover is a Y Combinator-backed startup working to make addiction treatment for low-income people more effective and accessible. We work with governments to use telehealth and medicine to improve outcomes for people who need treatment. We are growing fast and need people to grow with us. Over 46 million Americans struggle with addiction, and less than 10% receive treatment. For those that do, traditional treatment only works for ~8%. By integrating medical care, outcomes can be
Keywords: compliance need people recover treatment
Find related items on AmazonPublished on: 2025-09-10 23:29:56
They say that beauty is pain, and now that I've had a Sofwave treatment, I can confirm that this statement rings true. But is it less painful than a face lift? It certainly has less down time after the procedure. Sofwave was initially pitched to me as a way to firm up facial skin due to the common-yet-unpopular phenomenon known as "Ozempic Face," in which a drastic amount of weight loss can cause a person's skin to sag. I'm not on Ozempic, but I was curious. Due to my depressive eyebrows (ugh,
Keywords: face results skin sofwave treatment
Find related items on AmazonPublished on: 2025-10-10 03:30:38
If you’ve ever had trouble recovering from a bad back, you’re far from alone. A study out this week has found that only about 10% of common back pain treatments appear to provide any noticeable relief, and just barely at that. Scientists in Australia led the research, published Tuesday in BMJ Evidence Based Medicine. The researchers analyzed data from hundreds of clinical trials testing out dozens of back pain remedies, and found that only a few truly seemed more effective than placebo. These t
Keywords: chronic non pain placebo treatments
Find related items on AmazonPublished on: 2025-11-11 02:24:22
Glioblastoma is a highly aggressive and lethal brain cancer with an average survival time of 12 to 18 months. Only 25% of patients survive more than one year and less than 5% survive more than 3 years. The new publication shares the experimental treatment given to a patient diagnosed with glioblastoma. Prof Long used her expertise in immunotherapy and drew on melanoma science to devise, lead and administer the treatment. It is the first documented use of neoadjuvant triple immunotherapy in gl
Keywords: cells glioblastoma immune immunotherapy treatment
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