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Gut bacterium Bacteroides uniformis found to cut arterial plaque in mice

Researchers at Sun Yat-sen University identified a molecule produced by the gut microbe Bacteroides uniformis that lowered cholesterol and reduced arterial plaque by roughly half in mice, according to a study published in Nature. The compound appears to act through the same biological pathway used by statins, the cholesterol-lowering drugs taken by hundreds of millions of people.

Study links Australia's fiercer bushfires to end of Indigenous burning after colonization

A Nature study reconstructing 1,000 years of fire history in southeastern Australia found that British colonization halted Indigenous burning practices, allowing open, grassy landscapes to turn into dense, flammable forests. Researchers analysed a sediment core from Croajingolong National Park, land traditionally managed by the Gunaikurnai people, who were forcibly removed in the mid-1800s.

Study finds gut microbes shared by Hadza and Tsimane trace ancient human migrations

Researchers led by Carter et al., writing in Nature, compared gut microbiota of Tanzania's Hadza people with Bolivia's Tsimane people, whose ancestors diverged tens of thousands of years ago. They found hundreds of microbial species common to both groups, with genetic differences between strains aligning with the timing of prehistoric human migrations. Many of these shared microbes are now rare or absent in people living in industrialized regions.

Researchers retrofit token-based LLMs to read text at the byte level

A study published in Nature by Minixhofer and colleagues introduces 'byteification,' a method for converting existing token-based large language models so they can process text as individual bytes rather than whole word fragments. The authors report that byteified models retain the ability to identify individual characters within words while still matching the performance of standard token-based models.

Two teams report first working nuclear clocks in Nature

Two research groups, led by Toscani De Col and by Huang, have published the first demonstrations of a working nuclear clock in Nature. Unlike atomic clocks, which track electron transitions, these devices measure energy transitions within atomic nuclei, offering a potentially more precise timekeeping method. The Toscani De Col team also showed their clock could be used to search for a candidate form of dark matter.

Study finds genome accessibility data exposes disease risk missed by gene expression

Researchers report that measuring chromatin accessibility—which regions of DNA are open and available for activity—can reveal disease-associated genetic signals that standard gene expression analysis fails to capture. The findings come from a study published via Nature's research platform, though specific methods and disease models were not detailed in the available text.

Oxford neuroscience lab replaces slide talks with silent-reading memo meetings

Manuel Spitschan's circadian-neuroscience laboratory adopted a 'memo meeting' format, borrowed from Amazon, in April 2024. Each month the team spends 20 minutes silently reading a six-page memo written by one member, then discusses it for 70 minutes; separate weekly check-ins still cover logistics. Since starting, the group has produced around 50,000 words of memos covering topics from experiment design to a postdoc's career uncertainty.

ALIMA doctor details frontline response to DRC's Bundibugyo Ebola outbreak

An Ebola outbreak caused by the rare Bundibugyo virus was declared in the Democratic Republic of the Congo and Uganda on 15 May, with cases in the DRC reaching 7,890 and deaths around 3,799 by 23 September, a fatality rate near 48%. No licensed vaccine or treatment exists for this viral species, though two candidate vaccines and several experimental drugs are in clinical trials. Richard Kojan, an intensive-care physician with ALIMA, has been treating patients at treatment centres in the DRC, where symptoms mirror the more lethal Zaire Ebola species and many patients die of multi-organ failure after arriving in shock.

UN's 2030 goal to end AIDS epidemic faces mounting setbacks, researchers warn

In 2016 the United Nations set Sustainable Development Goal 3.3, pledging to end the AIDS epidemic by 2030 alongside other communicable diseases. More than 44 million people have died of AIDS-related causes since the disease was first identified in 1983, and roughly 41 million people currently live with HIV. Despite antiretroviral drugs that can suppress the virus and prevent transmission, no cure or vaccine yet exists, and researchers quoted say prevention efforts have been weakening.

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