Tech News
← Back to articles

iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion

read original related products more articles

Bressan, D., Battistoni, G. & Hannon, G. J. The dawn of spatial omics. Science 381, eabq4964 (2023).

Li, L. et al. Spatially resolved proteomics via tissue expansion. Nat. Commun. 13, 7242 (2022).

Luo, R. et al. A novel missense variant in ACAA1 contributes to early-onset Alzheimer’s disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline. Signal. Transduct. Target. Ther. 6, 325 (2021).

Giesen, C. et al. Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry. Nat. Methods 11, 417–422 (2014).

Goltsev, Y. et al. Deep profiling of mouse splenic architecture with CODEX multiplexed imaging. Cell 174, 968–981 (2018).

Hickey, J. W. et al. Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging. Nat. Methods 19, 284–295 (2022).

Mund, A. et al. Deep Visual Proteomics defines single-cell identity and heterogeneity. Nat. Biotechnol. 40, 1231–1240 (2022).

Bhatia, H. S. et al. Spatial proteomics in three-dimensional intact specimens. Cell 185, 5040–5058 (2022).

Ma, M. et al. In-depth mapping of protein localizations in whole tissue by micro-scaffold assisted spatial proteomics (MASP). Nat. Commun. 13, 7736 (2022).

Zubair, F. MALDI mass spectrometry based proteomics for drug discovery & development. Drug Discov. Today Technol. 40, 29–35 (2021).

... continue reading