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Researchers are trying to make human sperm (shown here in a colourized electron microscope image) from stem cells in the lab.Credit: Juergen Berger/Science Photo Library
Scientists have successfully engineered human blood cells so they transform into immature sperm, and incubated these cells in a tiny pouch grown on a mouse’s kidney. The blood cells were reprogrammed into induced pluripotent stem cells, which the team could ‘coax’ into embryonic cells that can give rise to eggs or sperm. The researchers then mixed the immature cells with non-reproductive cells found in the testicles of developing mice, which provide the environment to support sperm development. The procedure is a step toward eventually making mature sperm cells in the lab.
Nature | 5 min read
Reference: Cell Stem Cell paper
The central conclusions of biomedical preprints rarely change during the peer review process, according to a study of more than 70,000 preprints. The study, which is itself currently a preprint, found that almost 40% of main conclusions were unchanged between preprint and journal-published versions of paper abstracts, and another 50% underwent only minor revisions. The authors say the findings suggest that preprints are a reliable source of information, although some scientists say the finding should be interpreted more cautiously. The study only included preprints that went on to be published in a journal, so didn’t assess the veracity of unpublished preprints.
Nature | 5 min read
Reference: bioRxiv preprint (not peer reviewed)
The US National Science Foundation (NSF) is planning to expropriate money from its core science programmes to fund an initiative from the White House Office of Science and Technology Policy (OSTP), say NSF staff members and an internal NSF ledger seen by Nature. The move would force the agency to rescind funding for research proposals that are nearly finalized. The OSTP did not respond to Nature’s request for comment, nor did the offices of the legislators that oversee the NSF’s spending plans. An NSF spokesperson denied reports that the funds would be redirected to a handful of so-called ‘X-Labs’ that focus on applied research. NSF staff members who spoke to Nature say they fear retaliation if they speak out, and are not allowed to pass on what they know to researchers. “We don’t know where the money’s going or what’s going on,” one said. “We cannot communicate to the community at all. We’re forbidden.”
Nature | 6 min read
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