Systems vaccinology and the architecture of human immunity

Fauci, A. S. & Folkers, G. K. Pandemic preparedness and response: lessons from COVID-19. J. Infect. Dis. 228, 422–425 (2023).

Rappuoli, R., Alter, G. & Pulendran, B. Transforming vaccinology. Cell 187, 5171–5194 (2024).

Pulendran, B., Li, S. & Nakaya, H. I. Systems vaccinology. Immunity 33, 516–529 (2010).

Pulendran, B. & Davis, M. M. The science and medicine of human immunology. Science https://doi.org/10.1126/science.aay4014 (2020).

Tomalka, J. A., Suthar, M. S., Deeks, S. G. & Sekaly, R. P. Fighting the SARS-CoV-2 pandemic requires a global approach to understanding the heterogeneity of vaccine responses. Nat. Immunol. 23, 360–370 (2022).

Pulendran, B. Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology. Nat. Rev. Immunol. 9, 741–747 (2009).

Pulendran, B. Systems vaccinology: probing humanity’s diverse immune systems with vaccines. Proc. Natl Acad. Sci. USA 111, 12300–12306 (2014).

Plotkin, S. A. Updates on immunologic correlates of vaccine-induced protection. Vaccine 38, 2250–2257 (2020).

Bernstein, A., Pulendran, B. & Rappuoli, R. Systems vaccinomics: the road ahead for vaccinology. Omics 15, 529–531 (2011).

Querec, T. et al. Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. J. Exp. Med. 203, 413–424 (2006).

... continue reading