GoKawiil
Tech News
Researchers analyzed immune responses from over 150 non-human primates infected during a prolonged Shigella outbreak at a research facility, identifying specific bacterial molecules and antibody binding sites linked to protective immunity. The findings, published in Science Translational Medicine, pinpoint precise structural targets that could inform vaccine design against multiple Shigella strains.
This bibliography compiles foundational studies establishing systems vaccinology, a field using genomics and machine learning to predict and understand vaccine-induced immunity in humans. Key cited works include the 2009 study by Querec and colleagues, which first showed that blood transcriptional signatures could predict antibody responses to the yellow fever vaccine, and related papers on multilineage immune activation and pandemic vaccine response variability.
Researchers studying mice found that rising testosterone levels during puberty appear to suppress the type of lung inflammation associated with asthma. This offers a possible biological explanation for why many boys who suffer from asthma in childhood see their symptoms diminish or disappear after puberty, a pattern long observed but poorly understood.