Researchers filtered the PostgreSQL version of the CHEMBL34 database to find pairs of compounds tested against the same protein target, assay, activity type and publication, where one molecule was a simple chemical modification of the other (such as swapping a hydrogen for fluorine or a carbon for nitrogen). This produced 191,732 parent-analogue pairs, which the team supplemented by synthesizing new analogues from 18 selected parent compounds using RDKit-driven enumeration of feasible single-atom substitutions, each capped at $400 per 10 mg.
nature.com
· 2026-09-16
Scientists are accelerating efforts to understand why some infections trigger lasting illnesses such as long COVID and ME/CFS. A 2024 estimate put the global number of long COVID cases at 400 million, costing roughly $1 trillion annually, spurring governments including the US and Germany to commit over $1.7 billion combined toward research into post-infection diseases.
nature.com
· 2026-09-02
This bibliography compiles foundational studies establishing systems vaccinology, a field using genomics and machine learning to predict and understand vaccine-induced immunity in humans. Key cited works include the 2009 study by Querec and colleagues, which first showed that blood transcriptional signatures could predict antibody responses to the yellow fever vaccine, and related papers on multilineage immune activation and pandemic vaccine response variability.
nature.com
· 2026-08-26
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