Researchers led by Jesse Poganik at Brigham and Women's Hospital transplanted young hearts into middle-aged mice and middle-aged hearts into young mice, implanting the extra organ in the neck to compare it with the original. Using three molecular 'aging clocks' to measure biological age, the team found that transplanted hearts largely took on the biological age profile of the recipient rather than retaining the age of the donor, a pattern also suggested by records from human heart transplant recipients.
technologyreview.com
· 2026-09-25
A dynomight.net essay examines why the liver can regrow after injury or partial removal while organs like kidneys and gums degrade permanently over time. The author contrasts human biology with animals like salamanders, which regenerate lost limbs, and notes menopause is rare across species except in humans and a handful of whales.
dynomight.substack.com
· 2026-09-24
Researchers studying dietary restriction in fruit flies report identifying a specific protein that appears to mediate the link between reduced food intake and extended lifespan. The finding, described in a new study, points to a molecular mechanism that may help explain how caloric restriction slows aging in this model organism.
nature.com
· 2026-09-23
Researchers analyzed prefrontal cortex tissue from 284 neurotypical donors aged 0 to 97, drawn from the NIMH HBCC and Mount Sinai NIH Neurobiobank collections, to build a single-cell transcriptomic atlas. Donors were screened using neuropathology criteria such as CERAD and Braak scores to exclude Alzheimer's, Parkinson's, schizophrenia, bipolar disorder and cognitive impairment, and were grouped into developmental, young, middle and late adulthood categories.
nature.com
· 2026-09-23
Cell biologist Junyue Cao of Rockefeller University argues that aging follows a structured, stepwise progression rather than being simple molecular wear and tear. Using single-cell genomic tools to track aging in mice across the body, his lab identified distinct stages marked by shifts in molecular signals and cell populations, resembling phases of embryonic development. Cao suggests this programmed decline likely starts before age 30 in humans.
quantamagazine.org
· 2026-09-22
Boston Longevity Week, an 11-day series of events including biomarker conferences, an AI hackathon and an investor pitch night with over 30 venture firms, culminates in a Translational Longevity Summit. The event's organizers argue the longevity field's core challenge isn't a lack of innovation or even regulation, but a failure to translate promising research into validated, clinically usable treatments.
entrepreneur.com
· 2026-09-18
New government data shows Japan now counts 107,677 residents aged 100 or older, retaining its status as the country with the most centenarians worldwide. Women make up 88% of this group, and the oldest citizens are Kishimoto Fuyo, 114, of Kyoto City, and Kato Hikaru, 112, of Kumamoto.
bbc.com
· 2026-09-17
Researchers testing an AI-designed anti-aging drug reported that it lowered participants' biological age, as measured by aging clocks, in every case in the trial. The drug's development leaned on artificial intelligence tools to identify compounds likely to slow or reverse aging markers in the body.
fastcompany.com
· 2026-09-09
Insilico Medicine's AI-designed drug rentosertib, originally developed to treat idiopathic pulmonary fibrosis, produced unexpected reductions in biological age markers during a phase 2a trial. Researchers reanalyzed blood samples from 42 of 71 Chinese trial participants using six computational aging clocks, finding treated patients showed younger predicted ages after 12 weeks compared to placebo recipients.
techspot.com
· 2026-09-08
Alex Zhavoronkov, founder and co-CEO of AI-driven drug discovery company Insilico, is pursuing research suggesting that a treatment developed for fibrosis may have broader anti-aging effects. His work sits within a long personal and scientific interest in longevity research.
wsj.com
· 2026-09-07
A new U.S. Census Bureau report finds that people aged 65 and older now outnumber young children worldwide for the first time. The bureau projects the share of people 65 and up will nearly double from 10.5% in 2025 to 19.6% by 2060, driven largely by falling birth rates and longer lifespans. Global population is expected to grow from about 8 billion to 10 billion by 2060, with over half that growth coming from the elderly population.
slashdot.org
· 2026-09-05
Researchers at UC Berkeley gave 20-month-old female mice daily low-dose subcutaneous semaglutide, the active ingredient in drugs like Ozempic and Wegovy, and compared them with saline-treated and calorie-restricted counterparts. Over months of treatment, the semaglutide group showed slowed markers of aging and, in a full lifespan cohort of about 80 mice, longer survival than untreated controls.
nature.com
· 2026-09-02
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