GoKawiil
Tech News
Researchers used mouse models with tamoxifen-inducible deletion of the Trgc1 gene, which encodes a component of the γδ T cell receptor, to study how these cells patrol tissues like skin and intestine. By selectively removing the receptor gene in specific cell populations and tracking receptor signaling with reporter mice, they examined how TCR expression influences γδ T cell behavior and distribution across tissues.
Researchers at Icahn School of Medicine at Mount Sinai used male and female C57BL/6J and GAD2-IRES-Cre mice to study a neural circuit linking the amygdala to the anterior hypothalamus. Using whole-brain imaging, optogenetic silencing and calcium imaging, they examined how this circuit influences an animal's sensitivity to stress. No sex differences were found in behavioral or neuronal measures, so sex was dropped as a variable in the final analysis.
Scientists at EPFL used mass spectrometry imaging (MALDI-MSI) alongside liquid chromatography-mass spectrometry and single-nucleus RNA sequencing to catalog lipid molecules across coronal brain sections from adult mice. The study included comparisons between male and female mice, as well as pregnant females, sampling six specific brain regions to examine how lipid composition varies by sex and physiological state.