GoKawiilEPFL researchers map lipid distribution across the mouse brain using MALDI-MSI
Scientists at EPFL used mass spectrometry imaging (MALDI-MSI) alongside liquid chromatography-mass spectrometry and single-nucleus RNA sequencing to catalog lipid molecules across coronal brain sections from adult mice. The study included comparisons between male and female mice, as well as pregnant females, sampling six specific brain regions to examine how lipid composition varies by sex and physiological state.
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Detailed lipid maps of the brain could help researchers understand how lipid composition relates to brain function, since lipids play structural and signaling roles in neural tissue. By comparing pregnant and non-pregnant mice, the work may reveal how hormonal or physiological changes during pregnancy alter brain lipid profiles, though the article does not draw conclusions about specific health implications.
- Researchers combined MALDI-MSI, LC-MS, and snRNA-seq to build a lipidomic atlas of the mouse brain
- The study sampled six specific brain regions to compare lipid profiles across sex and pregnancy status
- Brains were processed under strict cold-chain protocols to preserve lipid integrity for accurate measurement
Source: nature.com — Fusar Bassini, 2026-09-23
Published there as: “The lipidomic architecture of the mouse brain”
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