Researchers analyzed large collections of human and mouse RNA sequencing data—including bulk RNA-seq, TRAP-seq, single-nucleus and single-cell RNA-seq—to catalog known and previously unannotated microexons, short stretches of RNA that can be spliced into genes. Using a modified version of the MicroExonator pipeline alongside whole-genome sequencing and PsychENCODE/NIMH data, the team identified a regulatory pattern governing microexon inclusion and linked variation in this process to genetic changes found in people with autism.
nature.com
· 2026-10-14
Scientists at EPFL used mass spectrometry imaging (MALDI-MSI) alongside liquid chromatography-mass spectrometry and single-nucleus RNA sequencing to catalog lipid molecules across coronal brain sections from adult mice. The study included comparisons between male and female mice, as well as pregnant females, sampling six specific brain regions to examine how lipid composition varies by sex and physiological state.
nature.com
· 2026-09-23
Researchers from the PsychAD consortium describe training single-nucleus transcriptomic imputation models (snTIMs) using single-nucleus RNA sequencing data from more than 6 million nuclei drawn from brain tissue of 1,494 donors. The work involved dividing donors into ancestry groups, harmonizing genotype data across multiple sequencing and array platforms, and building ancestry-specific reference panels to align training and target cohorts, including data from the Million Veteran Program.
nature.com
· 2026-09-23
Researchers analyzed post-mortem retinal and brain tissue from multiple sclerosis patients and healthy controls, using single-nucleus RNA sequencing, immunohistochemistry and other molecular techniques. They identified an intracellular form of complement factor H within neurons that appears to protect these cells from damage during central nervous system inflammation, a mechanism distinct from the protein's known extracellular immune role.
nature.com
· 2026-09-02
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