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Car T Cell

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Experimental CAR T Immunotherapy Clears Cancer in 3-Year-Old Boy

Researchers report that a young boy's cancer went into remission after receiving an experimental form of CAR T cell therapy. The treatment is part of ongoing efforts to adapt CAR T technology, previously effective mainly against blood cancers, to target solid tumors.

In vivo CAR-T therapy shows early promise for multiple sclerosis in small trial

A phase of clinical testing involving sixteen patients with multiple sclerosis and related autoimmune disorders showed symptom improvement after researchers used a modified virus to instruct T cells inside the body to produce chimeric antigen receptors, targeting the B cells responsible for autoimmune attacks. The findings, published this week in The New England Journal of Medicine, mark one of the first demonstrations that CAR-T therapy can be generated directly inside a patient rather than engineered in a lab and reinfused.