Chromatin Accessibility

TenK10K study links 1,042 blood samples to chromatin accessibility atlas

Researchers built a single-cell chromatin accessibility atlas using blood samples from 1,042 individuals drawn from the TenK10K phase I cohort, combining the Tasmanian Ophthalmic Biobank, BioHeart and Liquid Biopsy Biobank cohorts. The team used 10X Genomics single-cell ATAC-seq technology on 952 of these donors to map genetic variants influencing chromatin accessibility, a step toward understanding disease risk at the cellular level.

nature.com · 2026-10-28

Researchers release population-scale immune multiome atlas linking regulatory variants to disease

A research consortium has published a large-scale multiome dataset profiling gene expression and chromatin accessibility across immune cell types in many individuals, generating single-cell eQTLs and chromatin accessibility QTLs. The dataset is designed to help pinpoint which genetic variants associated with disease actually alter gene regulation in specific immune cell states, building on prior efforts like GTEx, ENCODE and FinnGen.

nature.com · 2026-09-30