GoKawiilTenK10K study links 1,042 blood samples to chromatin accessibility atlas
Researchers built a single-cell chromatin accessibility atlas using blood samples from 1,042 individuals drawn from the TenK10K phase I cohort, combining the Tasmanian Ophthalmic Biobank, BioHeart and Liquid Biopsy Biobank cohorts. The team used 10X Genomics single-cell ATAC-seq technology on 952 of these donors to map genetic variants influencing chromatin accessibility, a step toward understanding disease risk at the cellular level.
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Large-scale single-cell chromatin maps like this could help researchers pinpoint how specific genetic variants alter gene regulation in individual immune cell types, potentially sharpening links between DNA variation and disease susceptibility. Because the dataset combines several existing biobanks, it may also serve as a resource other scientists can reuse for genetic and immunological studies, though its practical impact will depend on subsequent analyses built on this atlas.
- The atlas draws on 1,042 blood samples from three Australian cohorts: TOB, BioHeart and LBIO.
- 952 TOB donors were profiled with 10X Genomics single-cell ATAC-seq for genetic mapping of chromatin accessibility.
- The project received ethics approval from multiple Australian institutions and is part of the broader TenK10K initiative.
Source: nature.com — Xue, 2026-10-28
Published there as: “Genetic variants shape single-cell chromatin accessibility and disease risk”
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