Researchers built a single-cell chromatin accessibility atlas using blood samples from 1,042 individuals drawn from the TenK10K phase I cohort, combining the Tasmanian Ophthalmic Biobank, BioHeart and Liquid Biopsy Biobank cohorts. The team used 10X Genomics single-cell ATAC-seq technology on 952 of these donors to map genetic variants influencing chromatin accessibility, a step toward understanding disease risk at the cellular level.
nature.com
· 2026-10-28
Researchers combined blood samples from two Australian cohorts—the Tasmanian Ophthalmic Biobank and BioHEART—totaling 2,339 recruited individuals, narrowed after quality control to 1,925 people of European ancestry. They used single-cell sequencing to examine how both rare and common genetic variants influence gene expression patterns in individual immune cells.
nature.com
· 2026-10-28
Researchers published the first-phase results of TenK10K, an expansion of the earlier OneK1K study, in Nature. The project combines single-cell RNA sequencing with other molecular profiling methods to catalogue genetic variants affecting gene expression across cell types, drawing on a planned cohort of 10,000 diverse individuals.
nature.com
· 2026-10-28
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