GoKawiilTenK10K project maps gene-regulation variants across 50 million single cells
Researchers published the first-phase results of TenK10K, an expansion of the earlier OneK1K study, in Nature. The project combines single-cell RNA sequencing with other molecular profiling methods to catalogue genetic variants affecting gene expression across cell types, drawing on a planned cohort of 10,000 diverse individuals.
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By resolving genetic effects on gene expression down to individual cell types rather than whole tissues, this dataset could sharpen links between specific DNA variants and disease mechanisms. Such fine-grained maps may help researchers pinpoint which cell types mediate genetic risk for various conditions, potentially informing future drug targets, though translating these associations into therapies remains a separate challenge.
- TenK10K expands the earlier OneK1K project to a planned 10,000-person, 50-million-cell dataset
- Three companion papers in Nature report the project's first-phase findings
- The approach links genetic variants to gene regulation at single-cell resolution, which could aid disease research
Source: nature.com — Natri, 2026-10-28
Published there as: “Genetic variants that alter gene regulation in specific cell types are closely tied to disease”
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