GoKawiil
Tech News
New research indicates that stroke incidence among Americans younger than 55 has roughly doubled compared with rates recorded in the 1990s. Researchers say they have not yet identified a clear explanation for the rise in younger patients.
Measles case counts in the United States have surpassed 3,500 so far this year, already exceeding the full-year total recorded in 2025. Health officials note that roughly 10% of this year's cases were reported within just the past two weeks, indicating the outbreak's pace is accelerating rather than slowing.
A team of scientists has compiled a large single-cell gene-expression dataset mapping how brain cells change across aging in mice, published via a Nature-affiliated report. The dataset catalogs expression patterns across numerous cell types and brain regions, intended as a resource for the broader research community.
An NIH-funded partnership called the PsychAD Consortium has published the largest single-cell map of the human prefrontal cortex, drawing on sequencing data from more than six million cells from nearly 1,500 people. The findings appear across eight studies, including three papers in Nature, and detail gene activity in neurons, immune cells and vascular cells in this brain region tied to planning and emotional regulation.
A multi-institution research effort combined brain tissue samples from the Mount Sinai NIH Neurobiobank, the NIMH-IRP Human Brain Collection Core, and the Rush Alzheimer's Disease Center to create a harmonized dataset spanning over 1,400 samples. The team standardized clinical measures such as neuritic plaque density (CERAD scores) and cognitive impairment ratings across the different cohorts, alongside demographic and technical variables like age, sex, ancestry and postmortem interval, to enable consistent single-cell transcriptomic analysis of brain disorders.
Researchers analyzed geolocated outbreak data for 32 environmentally linked emerging infectious diseases, combining these with global datasets on socio-environmental factors such as land use, climate and biodiversity. Using disease-specific driver hypotheses developed with experts across virology, ecology and public health, they built geospatial statistical models to identify common human-caused patterns behind where outbreaks occur.
An analysis by researchers including the article's author found that women make up around 41% of participants in cardiovascular disease clinical trials generally, but only 18-20% in regenerative-medicine trials for the same condition. Self-identified non-binary people were largely absent from these studies, according to the 2021 analysis.
A man with a slow-progressing, genetically rare form of ALS became the first person to receive an antisense oligonucleotide therapy designed specifically to target his causal mutation. A year later, he reported improved symptoms and remains able to work as a physician, according to results published in Med.
Investors are reportedly re-entering rare-disease drug stocks after the departure of stricter FDA regulators under the Trump administration. The shift in agency leadership has reduced concerns about tougher approval hurdles that had previously discouraged investment in this biotech segment.
Researchers analyzed human brain tissue samples from people with and without Alzheimer's disease and identified more than 1,000 microproteins that had previously gone undetected. Dozens of these small proteins showed different expression levels in Alzheimer's-affected brains compared with healthy ones. Separately, a mouse study found that immune cells activated by gut infections can travel to the brain's protective membrane and remain there as a lasting defensive memory.
Researchers propose that Alzheimer's disease progresses through distinct molecular and cellular phases marked by biological thresholds, rather than a simple straight-line path from amyloid buildup to Tau pathology to neurodegeneration. At these thresholds, cells lose homeostatic balance and shift behavior, with these altered states spreading unevenly across brain tissue and eventually reaching regions critical to cognition. A key threshold identified is when amyloid triggers Tau phosphorylation, marking the transition from amyloid-driven tissue states to ones dominated by neuronal stress responses.
Scientists at the Salk Institute and collaborators combined multiple detection techniques to identify over 4,300 previously unrecognized 'microproteins' in postmortem brain tissue from the dorsolateral prefrontal cortex, comparing samples from people with and without Alzheimer's disease. Dozens of these tiny proteins, each under 150 amino acids, showed altered levels in Alzheimer's patients, and the findings were published in Nature Aging on September 14.