Emx1 Cre - GoKawiil

Scientists Grow Human Brain Organoids Inside Mouse Cortex to Study Development

Researchers engineered mice with genetically depleted cortical tissue using Emx1-cre and Esco2 conditional knockout lines, then implanted human-derived brain organoids grown from induced pluripotent stem cells into the resulting cavity. The organoids were produced by aggregating dissociated hiPS cells in microwell plates and guiding them through early neural differentiation with dorsomorphin and SB-431542 before transplantation.

nature.com · 2026-09-16

Nature issues author correction for mouse brain atlas paper

The authors of the mouse brain stereotaxic atlas study published a correction fixing several errors: a mislabeled gene name in a figure (corrected to 'Emx1-Cre'), an inaccurate Dice score and sample size in Extended Data Fig. 4, and an updated voxel resolution value in the methods section describing whole-head dataset acquisition. The HTML and PDF versions of the paper have been updated accordingly, with the original figure included as supplementary material for comparison.

nature.com · 2026-09-07