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Genomics

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Researchers publish assembled genomes of 103 bat species spanning all 21 families

A study published in Nature by Morales and colleagues presents assembled genomes for 103 bat species, including 42 newly generated for the project, covering representatives of every known bat taxonomic family. The dataset gives scientists a broad genomic view of bat diversity and evolutionary history across the order Chiroptera.

Study maps gene regulatory changes behind human skeletal evolution

A Nature paper by Yan et al. used genomics tools to catalog genetic variants, genes and pathways that distinguish the human skeleton from those of chimpanzees, bonobos and gorillas. The work builds on the long-standing idea that human-ape differences arise more from regulatory changes in gene expression than from changes in protein-coding sequences themselves.

Study catalogues human-specific gene-regulatory changes shaping the skeleton

Researchers compared genomes from over 100 non-human great apes—including bonobos, chimpanzees, gorillas and orangutans—against thousands of human genomes to identify DNA substitutions unique and fixed in humans. They applied strict filtering criteria involving sequencing depth, genotype quality and allelic balance, then cross-checked results against archaic human genomes from Neanderthals and Denisovans, producing a curated set of human-specific variants for further functional testing via a massively parallel reporter assay (MPRA).

Rockefeller researcher Junyue Cao maps aging as a programmed sequence, not random decay

Cell biologist Junyue Cao of Rockefeller University argues that aging follows a structured, stepwise progression rather than being simple molecular wear and tear. Using single-cell genomic tools to track aging in mice across the body, his lab identified distinct stages marked by shifts in molecular signals and cell populations, resembling phases of embryonic development. Cao suggests this programmed decline likely starts before age 30 in humans.

Scientists grow rare Asgard archaea in lab, illuminating eukaryote origins

Researchers have managed to culture Asgard archaea, elusive microbes first identified from deep-sea sediment DNA in 2015, allowing direct study beyond genetic sequencing alone. One such culture, dubbed 'Skadi,' was recently transported across the US by a scientist determined to keep it alive and stable for continued research.

Google's AlphaGenome Atlas maps effects of every possible single-base DNA mutation

Google has released AlphaGenome Atlas, a tool that predicts the functional impact of swapping in any of the three alternative bases at every position across the roughly 3-billion-base human genome, amounting to 9 billion base substitutions analyzed. The system focuses heavily on non-coding DNA, which makes up over 97% of the genome and includes regulatory elements that control gene activity alongside leftover viral sequences with no clear function.

Google DeepMind releases AlphaGenome Atlas covering 9 billion DNA variants

DeepMind has published the AlphaGenome Atlas, a free online database containing precomputed predictions for every possible single-letter change across the human reference genome—about 9 billion variants. Built on its AlphaGenome model introduced earlier in 2025 and detailed in a January Nature paper, the Atlas lets scientists browse results through a web interface instead of writing code or running the model themselves.