GoKawiilScientists Grow Human Brain Organoids Inside Mouse Cortex to Study Development
Researchers engineered mice with genetically depleted cortical tissue using Emx1-cre and Esco2 conditional knockout lines, then implanted human-derived brain organoids grown from induced pluripotent stem cells into the resulting cavity. The organoids were produced by aggregating dissociated hiPS cells in microwell plates and guiding them through early neural differentiation with dorsomorphin and SB-431542 before transplantation.