GoKawiilMexico City cohort study links genetic ancestry variation within families to health traits
Researchers analyzed genome-wide data from over 140,000 participants in the Mexico City Prospective Study, combining it with reference panels from the 1000 Genomes Project and Human Genome Diversity Project to estimate individual ancestry proportions across Indigenous American, European, African and East Asian populations. Using an ADMIXTURE model with four ancestral groups, they examined how differences in ancestry proportions among siblings within the same family relate to complex traits, isolating genetic ancestry effects from shared environmental and socioeconomic factors.